Phase II Avastin Trial for Stage IIIB/IV NSCLC



Status:Archived
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:October 2008
End Date:August 2013

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A Multicenter, Open-Label, Randomized, Phase II Trial of Docetaxel, Carboplatin and Bevacizumab as First-Line Treatment, Followed by Bevacizumab Plus Pemetrexed Versus Pemetrexed Alone as Second-Line Treatment of Stage IIIB or IV Non-Small Cell Lung Cancer


This is a randomized, open-label, multicenter study in 160 patients in first line treatment
and 114 in second line treatment with advanced or metastatic NSCLC (Stage IIIB/IV).


This phase II clinical trial will address the issues of bevacizumab treatment duration and
treatment safety as first-line therapy for patients with non-squamous NSCLC. Following
disease progression or treatment failure, the potential benefit of continued bevacizumab
therapy will be tested by randomizing patients to two treatment arms, including second-line
chemotherapy with or without further bevacizumab. It is hypothesized that continuation of
bevacizumab with pemetrexed as second-line treatment following progression will result in
improved clinical outcomes for patients with NSCLC.


We found this trial at
32
sites
Richardson, Texas 75080
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Richardson, TX
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2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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Bremerton, WA
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12781 World Plaza Ln # 1
Fort Myers, Florida 33907
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Fort Myers, FL
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Aiken, South Carolina 29801
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Aiken, SC
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Akron, Ohio 44304
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Akron, OH
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Austin, Texas 78759
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Austin, TX
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Baton Rouge, Louisiana 70809
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Baton Rouge, LA
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Bedford, Ohio 44146
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Bedford, OH
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5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
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Cincinnati, OH
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Dubuque, Iowa 52001
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Dubuque, IA
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Elk Grove Village, Illinois 60007
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Elk Grove Village, IL
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Freesoil, MI
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Gettysburg, Pennsylvania 17325
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Gettysburg, PA
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Hazard, Kentucky 41701
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Hazard, KY
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500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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Hershey, PA
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Johnson City, Tennessee 37604
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Johnson City, TN
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Knoxville, Tennessee 37920
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Knoxville, TN
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Lafayette, Indiana 47904
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Lafayette, IN
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Lancaster, Pennsylvania 17601
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Lancaster, PA
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Las Vegas, Nevada 89106
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Las Vegas, NV
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Lincoln, Nebraska 68506
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Lincoln, NE
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Louisville, Kentucky 40202
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Louisville, KY
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Middletown, OH
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Mission Hills, California 91345
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Mount Clemens, Michigan 48043
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Muscle Shoals, Alabama 35661
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Orange, California 92868
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Port Huron, Michigan 48060
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Redding, California 96001
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Redding, CA
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St Louis, Missouri 63128
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St Louis, MO
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Woodbridge, Virginia 22191
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Woodbridge, VA
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Woonsocket, Rhode Island 02895
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Woonsocket, RI
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