Lipoic Acid and Prevention of Heart Disease

The purpose of this study is to see if a dietary supplement, R-alpha lipoic acid, is able to
reduce risk factors such as body weight and high blood cholesterol levels in overweight or
obese participants.

Recruitment will be in the Portland, Oregon area.

Inclusion Criteria:

- Age 18-60

- Overweight (BMI, 25.0-29.9 kg/m2) or obese (BMI, >30 kg/m2);

- Elevated plasma triglycerides (100-400 mg/dl);

- Weight stable for the last three months and at lifetime maximum;

- Exercise limited to 30 minutes 3 times a week or less;

- Hs-CRP level at baseline of ≤ 10 mg/L;

- Consuming ≤ 2 alcoholic drinks per day;

Exclusion criteria:

- Pregnant, breastfeeding, or planning to become pregnant before the end of the study.

- Having had acute medical conditions, such as hospitalizations or surgeries, at least
three months prior to entry into the study

- Diagnosed as having diabetes (fasting glucose <125 mg/dl for entry), cardiovascular
disease, congestive heart failure, angina, thyroid disorders, cancer, inflammatory
disorders or renal, hepatic, or hematological abnormalities;

- Currently taking lipid-lowering drugs, anti-hypertensive drugs, insulin , or oral
hypoglycemic agents, anti-inflammatory drugs, weight loss medications, or hormone
replacement therapy;

- On an extreme diet and not maintaining a prudent diet;

- Currently taking vitamin or antioxidant supplements, including R-alpha lipoic acid,
except standard multivitamin/mineral supplements containing not more than the Daily
Value (DV) of the vitamins and minerals;

- Smoking within the last three months;