Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches



Status:Completed
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:January 2008
End Date:July 2015

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The hypothesis of this study is that injection of botulinum toxin A into the muscles around
the head (frontal, temporal, posterior neck, occipital) can reduce the intensity and
frequency of migraine headaches by 50%.

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Inclusion Criteria:

- Adults 18 and older

- Migraine for more than three months, that fail to respond to two or more major
anti-migraine drug, meeting criteria of chronic migraine

Exclusion Criteria:

- Age below 18

- Pregnant or may become pregnant

- Disease of neuromuscular junction or drugs that affect N-M junction

- Allergy to Botox

- Previous use of Botox for migraine by similar methodology
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