Modified ABC: A Home-based Parenting Program for Opioid-dependent Mothers and Their Infants
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/29/2019 |
| Start Date: | August 13, 2018 |
| End Date: | August 31, 2021 |
| Contact: | Madelyn Labella, PhD |
| Email: | mlabella@psych.udel.edu |
| Phone: | 302-232-5170 |
Modified Attachment and Biobehavioral Catch-Up for Mothers and Their Infants
This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up
Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment
for opioid use disorder. The investigators expect that mothers who receive the modified
Attachment and Biobehavioral Catch-up Intervention will show more nurturing and sensitive
parenting and more adaptive physiological regulation than parents who receive a control
intervention. The investigators expect that infants whose mothers receive the modified
Attachment and Biobehavioral Catch-up will show better outcomes in attachment, behavior, and
physiological regulation compared to infants of parents who receive the control intervention.
Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment
for opioid use disorder. The investigators expect that mothers who receive the modified
Attachment and Biobehavioral Catch-up Intervention will show more nurturing and sensitive
parenting and more adaptive physiological regulation than parents who receive a control
intervention. The investigators expect that infants whose mothers receive the modified
Attachment and Biobehavioral Catch-up will show better outcomes in attachment, behavior, and
physiological regulation compared to infants of parents who receive the control intervention.
Peripartum mothers will be randomly assigned to receive the modified ABC intervention or the
control intervention (modified DEF). Hypotheses relate to parent and child outcomes
associated with the intervention.
Hypothesis 1: Compared to mothers who receive the control intervention, mothers who receive
the ABC intervention will show more nurturing and sensitive parenting, enhanced neural
activity during parenting-relevant tasks, and more normative patterns of DNA methylation,
autonomic nervous system activity, and cortisol production.
Hypothesis 2: Compared to infants of mothers who receive the control intervention, infants of
mothers who receive the ABC intervention will show more organized and secure attachment
patterns, better behavioral regulation during stressors, more advanced social-emotional
development, and more normative patterns of DNA methylation, autonomic nervous system
activity, and cortisol production.
Hypothesis 3: Enhanced maternal sensitivity will mediate effects of the ABC intervention on
improved infant outcomes.
control intervention (modified DEF). Hypotheses relate to parent and child outcomes
associated with the intervention.
Hypothesis 1: Compared to mothers who receive the control intervention, mothers who receive
the ABC intervention will show more nurturing and sensitive parenting, enhanced neural
activity during parenting-relevant tasks, and more normative patterns of DNA methylation,
autonomic nervous system activity, and cortisol production.
Hypothesis 2: Compared to infants of mothers who receive the control intervention, infants of
mothers who receive the ABC intervention will show more organized and secure attachment
patterns, better behavioral regulation during stressors, more advanced social-emotional
development, and more normative patterns of DNA methylation, autonomic nervous system
activity, and cortisol production.
Hypothesis 3: Enhanced maternal sensitivity will mediate effects of the ABC intervention on
improved infant outcomes.
Inclusion Criteria:
- In third trimester of pregnancy or up to one month postpartum
- Receiving medication-assisted treatment for opioid use disorder
Exclusion Criteria:
We found this trial at
1
site
Newark, Delaware 19716
Principal Investigator: Mary Dozier, PhD
Phone: 302-232-5170
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