The Influence of Non-Caloric Artificial Sweeteners on Youth With Type 1 Diabetes
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 5 - 17 |
| Updated: | 3/28/2019 |
| Start Date: | May 1, 2019 |
| End Date: | January 1, 2020 |
| Contact: | Susanne Cabrera, MD |
| Email: | t1dinfo@mcw.edu |
| Phone: | 414-955-4903 |
The Influence of Non-Caloric Artificial Sweeteners on the Metabolome, Body Composition, and Glycemic Control in Youth With Type 1 Diabetes
The investigators aim to further the understanding of environmental factors that may underlie
variations in body composition seen in youth with Type 1 diabetes (T1D). Non-caloric
artificial sweeteners, broadly consumed in many individuals with T1D, are a modifiable
dietary factor that may be associated with negative health outcomes, particularly those
relevant to the future risk of diabetes-related complications.
Investigators will measure body composition (the amount of fat and muscle in the body and
where the fat is stored) using a bioelectrical impedance analysis machine and DEXA scanner.
Blood will be drawn for the following labs: HbA1c, lipid panel, comprehensive metabolic panel
and leptin. Participants will also answer questions about their diets and consumption of
artificial sweeteners.
variations in body composition seen in youth with Type 1 diabetes (T1D). Non-caloric
artificial sweeteners, broadly consumed in many individuals with T1D, are a modifiable
dietary factor that may be associated with negative health outcomes, particularly those
relevant to the future risk of diabetes-related complications.
Investigators will measure body composition (the amount of fat and muscle in the body and
where the fat is stored) using a bioelectrical impedance analysis machine and DEXA scanner.
Blood will be drawn for the following labs: HbA1c, lipid panel, comprehensive metabolic panel
and leptin. Participants will also answer questions about their diets and consumption of
artificial sweeteners.
Inclusion Criteria:
1. Males and females aged 5-17 years with a clinical diagnosis of T1D of ≥ 6 months in
duration
2. BMI between the 5th and 95th percentile
Exclusion Criteria:
1. Presence of severe, active disease that requires the use of chronic medication, with
the exception of well-controlled autoimmune thyroiditis/hypothyroidism or celiac
disease that is well-controlled on a gluten free diet.
2. Diabetes other than T1D
3. Chronic illness known to affect glucose metabolism
4. Psychiatric impairment, with the exception of well-controlled depression or anxiety,
that will affect the ability to participate in the study
5. Female participants of child-bearing age with reproductive potential must not be
knowingly pregnant
6. Any condition that, in the investigator's opinion, may compromise study participation
or may confound the interpretation of the study results
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