Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome



Status:Completed
Conditions:Bronchitis, Hospital, Women's Studies
Therapuetic Areas:Pulmonary / Respiratory Diseases, Other, Reproductive
Healthy:No
Age Range:Any
Updated:3/24/2019
Start Date:January 1991
End Date:January 1992

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Efficacy and Safety of Exosurf Neonatal and Survanta for the Treatment of Respiratory Distress Syndrome

The purpose of this study is to compare the efficacy of two surfactants, Exosurf Neonatal
(Burroughs Wellcome Co.) and Survanta (Ross Laboratories), for the treatment of neonatal
respiratory distress syndrome.

The NICHD Neonatal Research Network conducted a randomized trial at 11 centers comparing the
efficacy of two surfactants -- Exosurf Neonatal (Burroughs Wellcome Co.) and Survanta (Ross
Laboratories) -- for the treatment of neonatal respiratory distress syndrome. Newborn infants
with birth weights of 501-1500g with respiratory distress syndrome who were receiving
assisted ventilation with 30% oxygen or more within 6 hours of birth were enrolled between
January 1991 and January 1992. Infants were randomly assigned to receive up to four
intratracheal doses of either Exosurf Neonatal or Survanta.

Inclusion Criteria:

- Newborn infants weighing 501 to 1500 gm with respiratory distress syndrome were
receiving assisted ventilation with 30% oxygen or more

Exclusion Criteria:

- Less than 6 hours of age
We found this trial at
13
sites
Albuquerque, New Mexico 87131
(505) 277-0111
University of New Mexico Founded in 1889 as New Mexico’s flagship institution, the University of...
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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85 S Prospect St
Burlington, Vermont 5405
(802) 656-3131
University of Vermont The University of Vermont combines faculty-student relationships most commonly found in a...
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Burlington, VT
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5323 Harry Hines Blvd
Dallas, Texas 75235
(214) 648-3111
Univ of Texas, Southwestern Med Ctr of Dallas The story of UT Southwestern Medical Center...
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Dallas, TX
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5050 Anthony Wayne Dr
Detroit, Michigan 48201
(313) 577-2424
Wayne State University Founded in 1868, Wayne State University is a nationally recognized metropolitan research...
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Detroit, MI
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425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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Indianapolis, IN
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920 Madison Ave
Memphis, Tennessee 38163
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Memphis, TN
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Miami, Florida 33124
(305) 284-2211
University of Miami A private research university with more than 15,000 students from around the...
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Miami, FL
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Cincinnati, Ohio 45267
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Cincinnati, OH
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Cleveland, OH
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New Haven, Connecticut 6520
(203) 432-4771
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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New Haven, CT
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Palo Alto, California 94304
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Washington, District of Columbia 20052
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Washington,
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