Pharmacokinetic Profile and Dermatomal Coverage of the Erector Spinae Plane Block
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Angina, Post-Surgical Pain |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/16/2019 |
| Start Date: | July 1, 2019 |
| End Date: | December 31, 2020 |
| Contact: | John Butterworth, MD |
| Email: | john.butterworth@vcuhealth.org |
| Phone: | (804) 828-9160 |
Pharmacokinetic Profile and Dermatomal Coverage of the Erector Spinae Plane Block: a Comparison of Bolus Dosing and Continuous Infusion
The goals of this study are as follows:
1. to confirm the safe dosing of ropivacaine for the erector spinae plane block
2. develop a pharmacokinetic profile of the erector spinae plane block, which will help
demonstrate how quickly and how closely toxic levels are reached when a routine dose of
ropivacaine is given for this nerve block
3. assess numbness created by the erector spinae block when routine doses are administered
1. to confirm the safe dosing of ropivacaine for the erector spinae plane block
2. develop a pharmacokinetic profile of the erector spinae plane block, which will help
demonstrate how quickly and how closely toxic levels are reached when a routine dose of
ropivacaine is given for this nerve block
3. assess numbness created by the erector spinae block when routine doses are administered
Inclusion Criteria:
1. Participant's age is greater than 18 years
2. Participant is undergoing a primary coronary artery bypass grafting surgery or heart
valve replacement that requires a midline sternotomy incision
3. Participant's surgery is being performed by Dr. Vig Kasirajan
Exclusion Criteria:
1. Diagnosis of cirrhosis, hepatitis, primary sclerosing cholangitis
2. Abnormal liver function tests demonstrated by lab results
3. Allergy to lidocaine, ropivacaine, or midazolam
4. Morbid obesity, defined as body mass index greater than 40
5. Existing skin neuropathy on the chest or back
6. Body weight less than 50 kg
7. Participant is not able to provide verbal feedback, such as when the participant
develops altered mental status or requires prolonged mechanical ventilation and
sedation
8. Participant remains intubated on post-operative day 1
9. Pregnant women
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