Rapid On Site Evaluation of Pleural Touch Preparations in Diagnosing Malignant Pleural Effusion in Patients Undergoing Pleuroscopy
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/13/2019 |
| Start Date: | January 10, 2018 |
| End Date: | June 30, 2019 |
| Contact: | Horiana Grosu |
| Email: | hbgrosu@mdanderson.org |
| Phone: | 713-792-6238 |
A Pilot Study to Evaluate the Diagnostic Performance of Pleural Touch Preparations in Pleuroscopy, a Prospective Study
This trial studies how well rapid on site evaluation of pleural touch preparations works in
diagnosing cancerous fluid in between the linings of the lungs (malignant pleural effusion)
in patients undergoing a pleuroscopy. A type of laboratory testing called rapid on site
evaluation of pleural touch preparations that uses pleural biopsy tissue samples collected
during an already-scheduled pleuroscopy may be able to diagnose malignant pleural effusion.
diagnosing cancerous fluid in between the linings of the lungs (malignant pleural effusion)
in patients undergoing a pleuroscopy. A type of laboratory testing called rapid on site
evaluation of pleural touch preparations that uses pleural biopsy tissue samples collected
during an already-scheduled pleuroscopy may be able to diagnose malignant pleural effusion.
PRIMARY OBJECTIVES:
I. To estimate the specificity of rapid on site evaluation (ROSE) of touch preparations
(preps) for predicting malignancy on final pathology in pleuroscopy.
SECONDARY OBJECTIVES:
I. To estimate the sensitivity of rapid on site evaluation (ROSE) of touch preparations
(preps) for predicting malignancy on final pathology in pleuroscopy.
II. To estimate the specificity and sensitivity of visual assessment of pleura for predicting
malignancy on final pathology in pleuroscopy.
III. To compare the specificity and sensitivity of ROSE of touch preps between centers.
OUTLINE:
Patients undergo biopsy of the lining of the lung using pleuroscopy. Medical chart of
patients is also reviewed.
I. To estimate the specificity of rapid on site evaluation (ROSE) of touch preparations
(preps) for predicting malignancy on final pathology in pleuroscopy.
SECONDARY OBJECTIVES:
I. To estimate the sensitivity of rapid on site evaluation (ROSE) of touch preparations
(preps) for predicting malignancy on final pathology in pleuroscopy.
II. To estimate the specificity and sensitivity of visual assessment of pleura for predicting
malignancy on final pathology in pleuroscopy.
III. To compare the specificity and sensitivity of ROSE of touch preps between centers.
OUTLINE:
Patients undergo biopsy of the lining of the lung using pleuroscopy. Medical chart of
patients is also reviewed.
Inclusion Criteria:
- Patients who will undergo pleuroscopy with biopsy
Exclusion Criteria:
- Patients with known malignant pleural effusion
- Inability or unwillingness to give informed consent
We found this trial at
2
sites
Houston, Texas 77030
Principal Investigator: Horiana Grosu
Phone: 713-792-6238
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