Intraoperative Ketamine Versus Saline in Patients With Major Depressive Disorder Undergoing Anesthesia for Total Joint Surgery
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Depression, Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 3/7/2019 |
| Start Date: | April 2019 |
| End Date: | April 2020 |
Double-blind Trial of Intraoperative Ketamine Versus Saline in Patients With Major Depressive Disorder Undergoing Anesthesia for Total Joint Surgery
This study evaluates whether ketamine, given as part of an anesthetic, improves depression
symptoms in depressed patients undergoing total joint replacement surgery. Half of
participants will receive a ketamine infusion during surgery, while the other half will
receive a placebo (normal saline) during surgery.
symptoms in depressed patients undergoing total joint replacement surgery. Half of
participants will receive a ketamine infusion during surgery, while the other half will
receive a placebo (normal saline) during surgery.
Major Depressive Disorder (MDD) is widely prevalent among patients preparing to have surgery,
and is a known risk factor for complications after surgery, including wound infection,
myocardial infarction and opioid use disorder. Ketamine has emerged as an effective,
rapid-acting antidepressant therapy for patients with MDD, and may be a useful tool to
prevent MDD-related morbidity in the perioperative period. Ketamine has been well studied for
MDD in outpatient clinics where it is given as an infusion (0.5 mg/kg over 40 minutes) in
awake patients. Ketamine is often used as part of an anesthetic cocktail in sedated or
anesthetized patients, but it is unknown whether ketamine has an antidepressant effect in
this context. The investigators will determine whether a ketamine infusion, compared to
placebo (normal saline infusion), has an antidepressant effect when given during surgical
anesthesia. If ketamine is an effective antidepressant in this population under anesthesia,
its use could be incorporated into a set of interventions to minimize the perioperative
complications associated with MDD.
and is a known risk factor for complications after surgery, including wound infection,
myocardial infarction and opioid use disorder. Ketamine has emerged as an effective,
rapid-acting antidepressant therapy for patients with MDD, and may be a useful tool to
prevent MDD-related morbidity in the perioperative period. Ketamine has been well studied for
MDD in outpatient clinics where it is given as an infusion (0.5 mg/kg over 40 minutes) in
awake patients. Ketamine is often used as part of an anesthetic cocktail in sedated or
anesthetized patients, but it is unknown whether ketamine has an antidepressant effect in
this context. The investigators will determine whether a ketamine infusion, compared to
placebo (normal saline infusion), has an antidepressant effect when given during surgical
anesthesia. If ketamine is an effective antidepressant in this population under anesthesia,
its use could be incorporated into a set of interventions to minimize the perioperative
complications associated with MDD.
Inclusion Criteria:
- Patient presenting for primary total joint arthroplasty
- Major Depressive Disorder
Exclusion Criteria:
- Pregnant of breastfeeding women
We found this trial at
1
site
Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
Click here to add this to my saved trials
