Gallium Ga 68-DOTATATE PET/CT in Diagnosing Patients With Metastatic Castration Resistant Prostate Cancer



Status:Recruiting
Conditions:Prostate Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/6/2019
Start Date:February 22, 2018
End Date:February 28, 2022
Contact:Mehmet Asim Bilen, MD
Email:mbilen@emory.edu
Phone:404-778-3448

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Molecular Imaging With Ga-68 DOTATATE PET to Investigate Neuroendocrine Differentiation in Prostate Cancer Patients

This pilot clinical trial studies how well gallium Ga 68-DOTATATE positron emission
tomography (PET)/computed tomography (CT) works in treating patients with castration
resistant prostate cancer that has spread to other placed in the body. Gallium Ga 68-DOTATATE
PET/CT may help doctors to identify those patients with early neuroendocrine
transdifferentiation and who are at greater risk for poor outcomes.

PRIMARY OBJECTIVE:

Establish the feasibility of using gallium Ga 68-DOTATATE (68Ga-DOTATATE) PET as a predictive
imaging biomarker for neuroendocrine transdifferentiation in prostate cancer.

SECONDARY OBJECTIVE:

Correlate progression of disease with degree of uptake on 68Ga-DOTATATE PET examination.

OUTLINE:

Patients receive gallium Ga 68-DOTATATE intravenously (IV). Within 55-70 minutes, patients
undergo PET/CT.

After completion of study, patients are followed up for at least 1 year.

Inclusion Criteria:

- Patients with metastatic castration resistant prostate carcinoma with skeletal,
visceral and/or nodal involvement

- Ability to lie still for PET scanning

- Patients must be able to provide written informed consent

Exclusion Criteria:

- Patients less than 18 years of age

- Patients without metastatic castration resistant prostate carcinoma with skeletal,
visceral and/or nodal involvement

- Inability to lie still for PET scanning

- Patients unable to provide written informed consent
We found this trial at
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Atlanta, Georgia 30322
Phone: 404-778-3448
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