Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Inclusion Criteria:

1. Subjects ≥ 18 years of age through ≤ 80 years of age

2. Subjects undergoing elective arthroscopic knee surgery, to include partial
meniscectomy, chondroplasty, or loose body removal.

Exclusion Criteria:

1. Previously enrolled in this study (enrolled for contralateral knee in this study)

2. Knee arthroscopy patients scheduled for knee ligament reconstructions

3. Bilateral knee arthroscopy

4. History of chronic opioid use or long-term analgesic therapy

5. Documented or suspected substance abuse

6. Currently on daily use of ibuprofen, acetaminophen or other pain altering medication,
including medications like Neurontin (gabapentin) and Ultram (tramadol)

7. Documented or suspected chronic pain syndrome

8. Any known allergy or adverse reaction or contraindication to the components of
hydrocodone, acetaminophen, or ibuprofen

9. History or symptoms of any significant medical problem in the last year (i.e.,
arrhythmia, impaired cardiovascular function, gastrointestinal bleeding, liver
disease, renal disease)

10. With active peptic ulcer disease (history of severe heartburn)

11. Symptoms of infection with initial enrollment

12. Pregnant or nursing

13. Diagnosis of cognitive impairment

14. Unable or unwilling to provide informed consent for surgery or enrollment in this
clinical study

15. Inability to understand the requirements of the study or be unwilling to provide
written informed consent (as evidenced by signature on an informed consent document
approved by Institutional Review Board) and agree to abide by the study restrictions.

16. Patient refusal

17. Currently taking Coumadin, Plavix, anticoagulation medications, or medications that
increase bleeding

18. Patients with other medical or psychological health conditions that preclude them from
either receiving the intervention or returning for follow-up visits.

19. Alcoholism