Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine



Status:Recruiting
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 80
Updated:3/22/2019
Start Date:March 11, 2019
End Date:January 22, 2021
Contact:Clinical Trials Registry Team
Email:IR-CTRegistration@allergan.com
Phone:877-277-8566

Use our guide to learn which trials are right for you!

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine (Progress)

This study will evaluate the efficacy, safety and tolerability of atogepant in participants
with chronic migraine. This study includes a 12-week treatment period.


Inclusion Criteria:

- At least a 1-year history of CM consistent with a diagnosis according to the ICHD-3,
2018

- Age of the participant at the time of migraine onset < 50 years

- Confirmation of headache/migraine headache day frequency as follows:

1. History of, on average, ≥ 15 headache days per month in the 3 months prior to
Visit 1 in the opinion of the investigator AND

2. ≥ 15 headache days during the 4-week screening/baseline period per the electronic
diary (eDiary) AND

3. ≥ 8 days during the 4-week screening/baseline period that qualify as being a
migraine day per the eDiary

- Participants must be using a medically acceptable and effective method of birth
control during the course of the entire study,

Exclusion Criteria:

- Has a history of migraine, accompanied by diplopia or decreased level of
consciousness, or retinal migraine

- Has a current diagnosis of new persistent daily headache, trigeminal autonomic
cephalgia (eg, cluster headache), or painful cranial neuropathy

- History of an inadequate response to > 4 medications (2 of which have different
mechanisms of action) prescribed for the prevention of migraine

- Woman is pregnant, planning to become pregnant during the course of the study, or
currently lactating. Women of childbearing potential must have a negative urine
pregnancy test at Visit 1 and Visit 2.
We found this trial at
27
sites
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Albany, New York 12208
?
mi
from
Albany, NY
Click here to add this to my saved trials
Amherst, New York 14226
?
mi
from
Amherst, NY
Click here to add this to my saved trials
Bellevue, Washington 98007
?
mi
from
Bellevue, WA
Click here to add this to my saved trials
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Covington, Louisiana 70433
?
mi
from
Covington, LA
Click here to add this to my saved trials
Dallas, Texas 75214
?
mi
from
Dallas, TX
Click here to add this to my saved trials
2201 Inwood Rd
Dallas, Texas 75235
(214) 645-8300
U.T. Southwestern Medical Center The story of UT Southwestern Medical Center is one of commitment...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Fresno, California 93723
?
mi
from
Fresno, CA
Click here to add this to my saved trials
Greensboro, North Carolina 27405
?
mi
from
Greensboro, NC
Click here to add this to my saved trials
Las Vegas, Nevada 89113
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Little Rock, Arkansas 72205
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
McLean, Virginia 22101
?
mi
from
McLean, VA
Click here to add this to my saved trials
Minneapolis, Minnesota 55402
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
Phoenix, Arizona 85013
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15243
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Raleigh, North Carolina 27607
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
Ridgeland, Mississippi 39157
?
mi
from
Ridgeland, MS
Click here to add this to my saved trials
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Sherman Oaks, California 91403
?
mi
from
Sherman Oaks, CA
Click here to add this to my saved trials
Tacoma, Washington 98409
?
mi
from
Tacoma, WA
Click here to add this to my saved trials
Victoria, British Columbia
?
mi
from
Victoria,
Click here to add this to my saved trials
Virginia Beach, Virginia 23456
?
mi
from
Virginia Beach, VA
Click here to add this to my saved trials
Washington, District of Columbia 20037
?
mi
from
Washington,
Click here to add this to my saved trials
West Palm Beach, Florida 33407
?
mi
from
West Palm Beach, FL
Click here to add this to my saved trials
Willow Grove, Pennsylvania 19090
?
mi
from
Willow Grove, PA
Click here to add this to my saved trials