Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Cancer, Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 2/23/2019 |
| Start Date: | May 1, 2019 |
| End Date: | December 31, 2022 |
Investigators propose to develop hyperpolarized [13C]-labeled pyruvate as potential imaging
probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism
and synthesis of a neurotransmitter.
probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism
and synthesis of a neurotransmitter.
Investigators will perform a pilot study to test the translational feasibility by evaluating
sensitivity and repeatability of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate in
healthy human subjects (n =10 each). Each subject will be imaged twice using the same
hyperpolarized substrate with an interval (<45min) between the injections to evaluate
repeatability. Finally, eight subjects will be imaged with both hyperpolarized
[1-13C]pyruvate and [2-13C]pyruvate for comparison.
sensitivity and repeatability of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate in
healthy human subjects (n =10 each). Each subject will be imaged twice using the same
hyperpolarized substrate with an interval (<45min) between the injections to evaluate
repeatability. Finally, eight subjects will be imaged with both hyperpolarized
[1-13C]pyruvate and [2-13C]pyruvate for comparison.
Inclusion Criteria:
- 18 through 60 years of age.
- Healthy, with no neurological abnormalities.
- Ability to understand and the willingness to sign a written informed consent.
- All races and ethnicities will be included; subjects must be able to read and speak
the English or Spanish language.
Exclusion Criteria:
- Metallic foreign bodies on the scalp or cranium which may interfere with MRI
acquisitions
- Major debilitating neurological disease including, but not limited to, stroke, CVA,
dementia and tumor that would limit compliance with study requirements
- Under influence of illicit drugs which are known to alter brain physiology/metabolism
including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana
at the time of MRI/MRSI scanning.
- Under influence of antiepileptic drugs at the time of MRI/MRSI scanning.
- Any contraindication per MRI Screening Form including
- Implants contraindicated at 3T, pacemakers
- Implantable Cardioverter Defibrillator (ICD)
- Claustrophobia
- Medically unstable including
- Heart failure
- Severe left ventricular outflow tract (LVOT) obstruction
- Unstable angina
- Pregnancy
- Lactating
We found this trial at
1
site
Click here to add this to my saved trials
