Cognitive Enhancement Through Transcranial Laser Therapy



Status:Recruiting
Conditions:Cognitive Studies, Cognitive Studies
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:45 - Any
Updated:2/23/2019
Start Date:February 21, 2016
End Date:August 2020
Contact:Andreana Haley, Ph.D.
Email:haley@austin.utexas.edu
Phone:512-232-0863

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This is a mechanism-driven translational project to test the efficacy of transcranial
low-level light/laser therapy (LLLT), for enhancing cognitive function in middle-aged and
older adults and participants with Mild Cognitive Impairment.

The goal of this project is to test the efficacy of LLLT to enhance neurocognitive function
in middle-aged adults and examine the modulating influences of carotid atherosclerosis. The
specific aims will be accomplished in a randomized controlled trial (RCT) by examining
cognitive test performance and blood oxygen level-dependent (BOLD) response to a working
memory task in middle-aged and older adults and participants with Mild Cognitive Impairment
pre- and post- six-week long intervention of LLLT or placebo. In addition, the investigators
will examine if carotid artery intima-media thickness (IMT) moderates the therapeutic effects
of LLLT.

Inclusion Criteria:

- Men and postmenopausal women, aged 45 and older

- Participants with Mild Cognitive Impairment

Exclusion Criteria:

- neurological disease (e.g., large vessel stroke, seizure disorder, Parkinson's
disease, Alzheimer's disease, clinically significant traumatic brain injury with loss
of consciousness > 30 minutes, multiple sclerosis, or brain infection/meningitis

- baseline IQ < 85 placing them below the average range of intellectual functioning

- major psychiatric illness (e.g., schizophrenia, bipolar disorder) or substance abuse
(diagnosed abuse and/or previous hospitalization for substance abuse)

- severe cardiovascular disease (e.g., pacemaker), chronic obstructive pulmonary
disease, liver or kidney disease, inflammatory illness
We found this trial at
1
site
Austin, Texas 78712
Principal Investigator: Andreana Haley, PhD
Phone: 512-471-7926
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