Genetic Predisposition to Food Cue Reactivity in Children



Status:Recruiting
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:8 - 12
Updated:3/27/2019
Start Date:January 10, 2019
End Date:December 31, 2024
Contact:Reina K Lansigan, MSSW
Email:reina.k.lansigan@dartmouth.edu
Phone:917-915-3686

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Trial Summary
Trial Overview
Inclusion Criteria

The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children

This study assesses the associations between genetic factors, food-cue-related neural
reactivity, self-regulatory capacity, eating in the absence of hunger (EAH), and adiposity
gain in children.

The investigators will assess the associations between genetic factors, food-cue-related
neural reactivity, eating in the absence of hunger (EAH) in response to food cues, and
adiposity gain in children. They will also determine whether self-regulatory capacity
modifies these associations. The genetic factors explored specifically include FTO, MC4R,
polymorphisms in genes involved in dopaminergic pathways, and a composite genetic risk score
built from genome-wide obesity-related loci.

Inclusion Criteria:

- English fluency

- Willingness to participate in all study visits

Exclusion Criteria:

- Relevant food allergies or dietary restrictions

- Metal in or on the body

- Claustrophobia

- Psychiatric and neurological disorders

- Relative in the study

- Appetite- or attention-altering medications or disorders
We found this trial at
1
site
Dartmouth-Hitchcock
Lebanon, New Hampshire 03756
Principal Investigator: Diane Gilbert-Diamond, ScD
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mi
from
Lebanon, NH
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