Veloxis de Novo Kidney Transplant ECSWD

Inclusion Criteria:

1. Male and female patients ≥ 18 years of age.

2. Patient who is receiving a renal transplant from a living or heart-beating deceased
donor.

3. Female patients of child bearing potential must have a negative urine or serum
pregnancy test within the past 48 hours prior to study inclusion.

4. The patient has given written informed consent to participate in the study

Exclusion Criteria:

1. Patient has previously received an organ transplant other than a kidney.

2. Patient is receiving an HLA identical living donor transplant.

3. Patient who is a recipient of a multiple organ transplant.

4. Patient has a most recent cytotoxic PRA of >25% or calculated PRA >50% where multiple
moderate level HLA antibodies exist and in the opinion of the PI represents
substantial HLA sensitization.

5. Patient with a positive T or B cell crossmatch that is primarily due to HLA
antibodies.

6. Patient with a donor specific antibody (DSA) as deemed by the PI to be associated with
significant risk of rejection.

7. Patient has received an ABO incompatible donor kidney.

8. The deceased donor and/or deceased donor kidney meet any of the following extended
criteria for organ donation (ECD):

1. Donor age ≥ 60 years OR

2. Donor age 50-59 years and 1 of the following:

i. Cerebrovascular accident (CVA) + hypertension + SCr > 1.5 mg/dL OR ii. CVA +
hypertension OR iii. CVA + SCr > 1.5 mg/dL OR iv. Hypertension + SCr > 1.5 mg/dL OR c.
CIT ≥ 24 hours, donor age > 10 years OR d. Donation after cardiac death (DCD)

9. Recipients will be receiving a dual or en bloc kidney transplant.

10. Donor anticipated cold ischemia is >30hours.

11. Recipient that is seropositive for hepatitis C virus (HCV) with detectable Hepatitis C
viral load are excluded. HCV seropositive patients with a negative HCV viral load
testing may be included.

12. Recipients receiving a kidney from a donor with HCV viremia (detected through nucleic
acid testing or other means)

13. Recipients with a positive hepatitis B viral load or positive hepatitis B surface
antigen testing within 1 year of consent.

14. Hepatitis B surface antibody negative recipients receiving a kidney from a donor
seropositive for hepatitis B core antibody or hepatitis B nucleic acid.

15. Recipient or donor is known to be seropositive for human immunodeficiency virus (HIV).

16. Recipient who is seronegative for Epstein Barr Virus (EBV)

17. Patient has uncontrolled concomitant infection or any other unstable medical condition
that could interfere with the study objectives.

18. Patients with thrombocytopenia (PLT <75,000/mm3), and/or leukopenia (WBC < 2,000/mm3),
or anemia (hemoglobin < 6 g/dL) prior to study inclusion.

19. Patient is taking or has been taking an investigational drug in the 30 days prior to
transplant.

20. Patient who has undergone desensitization therapy within 6 months prior to transplant.

21. Patient has a known hypersensitivity to tacrolimus, mycophenolate mofetil/mycophenolic
acid, rabbit anti-thymocyte globulin, or glucocorticoids.

22. Patient is receiving chronic steroid therapy at the time of transplant.

23. Patients with a history of cancer (other than non-melanoma skin cell cancers cured by
local resection) within the last 5 years, unless they have an expected disease free
survival of >95%.

24. Patient is pregnant, where pregnancy is defined as the state of a female after
conception and until the termination of gestation, confirmed by positive human
Chorionic Gonadotropin (hCG) laboratory test.

25. Women of childbearing potential must use reliable contraception simultaneously, unless
they are status post bilateral tubal ligation, bilateral oophorectomy, or
hysterectomy.

26. Patient has any form of substance abuse, psychiatric disorder or a condition that, in
the opinion of the investigator, may invalidate communication with the investigator.

27. Inability to cooperate or communicate with the investigator.

28. Renal allograft has been reperfused for more than 48 hours at the time of enrollment

29. Patient unable to receive intact LCPT formulation