Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib as First-line Therapy in Participants With Advanced Hepatocellular Carcinoma (MK-7902-002/E7080-G000-311/LEAP-002)

Conditions:Liver Cancer, Cancer
Therapuetic Areas:Oncology
Age Range:18 - Any
Start Date:December 31, 2018
End Date:July 23, 2022
Contact:Toll Free Number

Use our guide to learn which trials are right for you!

Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib in First-line Therapy of Participants With Advanced Hepatocellular Carcinoma (LEAP-002)

The purpose of this study is to evaluate the safety and efficacy of lenvatinib
(E7080/MK-7902) in combination with pembrolizumab (MK-3745) versus lenvatinib in combination
with placebo as first-line therapy for the treatment of advanced hepatocellular carcinoma in
adult participants.

The primary hypotheses of this study are that lenvatinib plus pembrolizumab is superior to
lenvatinib plus placebo with respect to progression-free survival (PFS) and overall survival

Inclusion Criteria:

- Is male or female and ≥18 years of age at the time of signing the informed consent

- Has a diagnosis of hepatocellular carcinoma confirmed by radiology, histology, or

- Has Barcelona Clinic Liver Cancer (BCLC) Stage C disease, or BCLC Stage B disease not
amenable to locoregional therapy or refractory to locoregional therapy, and not
amenable to a curative treatment approach

- Has a Child-Pugh class A liver score

- Has a predicted life expectancy of >3 months

- Has at least one measurable lesion based on RECIST 1.1 as confirmed by BICR

- Has an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 to 1

- Participants with hepatitis B will be eligible as long as their virus is well

Exclusion Criteria:

- Has had esophageal or gastric variceal bleeding within the last 6 months

- Has gastrointestinal malabsorption, gastrointestinal anastomosis, or any other
condition that might affect the absorption of lenvatinib

- Has a preexisting Grade ≥3 gastrointestinal or non-gastrointestinal fistula

- Has clinically significant hemoptysis from any source or tumor bleeding within 2 weeks
prior to the first dose of study intervention

- Has significant cardiovascular impairment within 12 months of the first dose of study
intervention such as history of congestive heart failure greater than New York Heart
Association (NYHA) Class II, unstable angina, myocardial infarction or cerebrovascular
accident stroke, or cardiac arrhythmia associated with hemodynamic instability

- Has had major surgery to the liver within 4 weeks prior to the first dose of study

- Has had a minor surgery (ie, simple excision) within 7 days prior to the first dose of
study intervention

- Has serious non-healing wound, ulcer, or bone fracture

- Has received any systemic chemotherapy for HCC or chemotherapy for any malignancy in
the past 3 years

- Has received prior therapy with an anti-programmed cell death 1 (ant-PD-1),
anti-programmed cell death ligand 1 (anti-PD-L1), or anti- programmed cell death
ligand 2 (anti-PD-L2) agent or with an agent directed to another stimulatory or
co-inhibitory T-cell receptor (eg, cytotoxic T-lymphocyte-associated protein 4
[CTLA-4], OX-40, or CD137)

- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
or any other form of immunosuppressive therapy within 7 days prior the first dose of
study intervention

- Has a known additional malignancy that is progressing or has required active treatment
within the past 3 years with the exceptions of basal cell carcinoma of the skin,
squamous cell carcinoma of the skin, or carcinoma in situ (eg, breast carcinoma,
cervical cancer in situ) that has undergone potentially curative therapy

- Has a known history of, or any evidence of, central nervous system (CNS) metastases
and/or carcinomatous meningitis as assessed by local site investigator

- Has severe hypersensitivity (≥Grade 3) to study intervention and/or any of their

- Has an active autoimmune disease that has required systemic treatment in past 2 years

- Has a history of (non-infectious) pneumonitis that required steroids or has current

- Has urine protein ≥1 grams/24 hours

- Prolongation of corrected QT (QTc) interval to >480 milliseconds (corrected by
Fridericia Formula)

- Has left ventricular ejection fraction (LVEF) below the institutional normal range as
determined by multigated acquisition scan (MUGA) or echocardiogram (ECHO)

- Has an active infection requiring systemic therapy with the exceptions of HBV or HCV

- Has a known history of human immunodeficiency virus (HIV) infection

- Has a known history of active tuberculosis (Bacillus tuberculosis)

- Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the study, interfere with the participant's
participation for the full duration of the study, or is not in the best interest of
the participant to participate, in the opinion of the treating investigator

- Has a known psychiatric or substance abuse disorder that would interfere with the
participant's ability to cooperate with the requirements of the study

- Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 120 days
after the last dose of study intervention

- Has had an allogenic tissue/solid organ transplant
We found this trial at
Oklahoma City, Oklahoma 73104
Phone: 405271800148955
Oklahoma City, OK
Click here to add this to my saved trials
1500 E Duarte Rd
Duarte, California 91010
(626) 256-4673
Phone: 626-218-9200
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
Duarte, CA
Click here to add this to my saved trials
Atlanta, Georgia 30322
Phone: 404-778-1900
Atlanta, GA
Click here to add this to my saved trials
Spokane, Washington 99218
Phone: 509-228-1000
Spokane, WA
Click here to add this to my saved trials
Wooloongabba, Queensland
Phone: +61731766577
Click here to add this to my saved trials