A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 127
Updated:3/28/2019
Start Date:December 27, 2018
End Date:December 25, 2020
Contact:AstraZeneca Clinical Study Information Center
Email:information.center@astrazeneca.com
Phone:1-877-240-9479

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A Phase IB, Open-Label, Multi-Center Study to Determine the Efficacy and Safety of Durvalumab in Combination With Novel Oncology Therapies, With or Without Chemotherapy, for First-Line Stage IV Non Small Cell Lung Cancer (NSCLC) (MAGELLAN)

This study is designed to determine the efficacy and safety of durvalumab in combination with
novel oncology therapies and with or without chemotherapy, for first-line Stage IV non small
cell lung cancer (NSCLC)

This is a Phase IB, Open-Label, Multi-Center Study to Determine the Efficacy and Safety of
Durvalumab in Combination With Novel Oncology Therapies, With or Without Chemotherapy, for
First-Line Stage IV Non Small Cell Lung Cancer (NSCLC).

Inclusion Criteria:

- Histologically or cytologically documented Stage IV NSCLC not amenable to curative
surgery or radiation

- No prior chemotherapy or any other systemic therapy for metastatic NSCLC

- Prior platinum-containing adjuvant, neoadjuvant, or definitive chemoradiation for
advanced disease are eligible, if progression has occurred >12 months from end of last
therapy

- Known tumor PD-L1 status

- WHO/ECOG status at 0 or 1 at enrollment

- Life expectancy of at least 12 weeks

Exclusion Criteria:

- Active or prior documented autoimmune or inflammatory disorders

- History of active primary immunodeficiency

- Any prior chemotherapy or any other systemic therapy for metastatic NSCLC

- Untreated CNS metastases
We found this trial at
8
sites
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Detroit, MI
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from
Bronx, NY
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Charlotte, North Carolina 28207
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from
Charlotte, NC
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from
Chicago, IL
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from
Iowa City, IA
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from
La Jolla, CA
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from
Nashville, TN
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from
Salzburg,
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