Effect of Macadamia Nut on Cardiometabolic Risk Factors
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 50 - 65 |
| Updated: | 1/16/2019 |
| Start Date: | March 2019 |
| End Date: | March 2021 |
| Contact: | Amandeep Kaur, MPH |
| Email: | akaur1@llu.edu |
| Phone: | 909-558-4300 |
Macadamia Nut Effects on Adiposity and Cardiometabolic Risk Factors
This research study will test the effects of macadamia nuts on adiposity, and traditional and
emergent risk factors of cardiometabolic disease in adult men and women
emergent risk factors of cardiometabolic disease in adult men and women
Purpose of this study is to investigate the effects of Macadamia nuts on body weight,
adiposity, , oxidative stress, glucose, insulin an lipid levels. it will a randomized cross
over study that will include two study diets (Macadamia nut diet and control diet) with a
wash out period of 4 weeks in between. 40 subjects will be selected and randomized into
either of the two phases. During the Macadamia nut diet phase subjects will be provided the
appropriate portion of Macadamia nuts (15% of daily calories or 30-45 grams based on kcal
requirement of the individual, instructions will be provided on how to incorporate nuts into
the diet. this phase will last for 8 weeks. During the control diet phase, subjects will
continue with their normal diet and abstain from eating nuts. subjects will be tested for
various outcomes at baseline and twice at the end of each phase. The intervention will last
for 5 months in total.
adiposity, , oxidative stress, glucose, insulin an lipid levels. it will a randomized cross
over study that will include two study diets (Macadamia nut diet and control diet) with a
wash out period of 4 weeks in between. 40 subjects will be selected and randomized into
either of the two phases. During the Macadamia nut diet phase subjects will be provided the
appropriate portion of Macadamia nuts (15% of daily calories or 30-45 grams based on kcal
requirement of the individual, instructions will be provided on how to incorporate nuts into
the diet. this phase will last for 8 weeks. During the control diet phase, subjects will
continue with their normal diet and abstain from eating nuts. subjects will be tested for
various outcomes at baseline and twice at the end of each phase. The intervention will last
for 5 months in total.
Inclusion Criteria:
- Healthy men and post-menopausal women
- Overweight (BMI 25-34)
- Waist circumference ≥88.9 cm for women and ≥101.6 cm for men
- At least one of the following within the past year:
- Plasma triglycerides ≥150mg/dl
- Blood Pressure ≥130/85 mmHg
- Fasting glucose ≥100 mg/dL
Exclusion Criteria:
- Nut allergy, any
- Significant chronic disease including: diabetes, congestive heart failure, renal
failure, cirrhosis, or autoimmune disease
- Medications affecting lipid or glucose metabolism, immune modulators, or antibiotics
in the last 6 months
- Mega-doses of lipid-lowering dietary supplements in the last 6 months
- Cancer in the last 10 years (with the exception on non-melanoma skin cancer)
- Pregnancy or lactation
- Weight change of >10% of body weight in the last 3 months
- Excessive caffeine intake (>2 cups/day) or alcohol intake (>1 drink/day for women, >2
drinks/day for men)
- Tobacco use
- Claustrophobia (may affect BOD POD testing)
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