Zero Sodium Peritoneal Dialysate Protocol Pilot Study

While heart failure (HF) is generally regarded as the inability of the heart to pump
sufficient blood, on a population level, volume overload is the primary driver of morbidity
and hospitalization. The signs and symptoms of volume overload are driven by water
accumulation, which is initially driven by sodium retention. This overall goal of this study
is to investigate the ability to remove sodium through use of a zero-sodium solution in
peritoneal dialysis.

Inclusion Criteria:

1. Patients actively undergoing peritoneal dialysis (PD) with a functioning PD catheter

2. PD vintage < 3 years

3. As judged by treating nephrologist to be at or above optimal volume status (i.e., not
dehydrated)

Exclusion Criteria:

1. Uncontrolled diabetes with frequent episodes of severe hyperglycemia

2. Systolic blood pressure < 100 mmHg

3. Serum sodium < 130 mEq/L

4. 1 or more episodes of peritonitis in the previous 6 months or active infection of the
peritoneal dialysis catheter

5. Anemia with hemoglobin <8 g/dL

6. Serum bicarbinate < 18 mEq/L

7. Anuric renal failure

8. Inability to give written informed consent or follow study protocol