Genetic and Epigenetic Basis of Chronic Wounds



Status:Recruiting
Conditions:Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:18 - 70
Updated:4/3/2019
Start Date:December 4, 2018
End Date:December 2020
Contact:Jennifer Mohnacky
Email:jmohnack@iu.edu
Phone:317-278-2715

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This pilot study is designed for chronic wounds that fail to heal in a timely manner carry
specific genetic signatures. These genetic signatures will be studied using debrided wound
tissue that is removed by the wound care provider as part of standard of care. The reference
genomic signature will be evaluated by obtaining blood samples and will be compared with
wound debrided tissue genomic signature to understand wound specific genomic changes.

Chronic wounds affect a large fraction of the world population and poses major threat to the
public health and economy of the United States affecting 6.5 million patients. It has been
estimated that approximately 2% of the population residing in developed countries, will
experience at least one chronic wound during their lifetime. Current treatment options for
chronic wounds are insufficient due to lack of individual specific genetic information. To
improve therapy, an increase in the investigator's understanding of the genetic
predisposition of individuals which result in impaired wound healing response is warranted.
Information about these individual specific genetic and epigenetic regulations can altogether
yield subset of repair genes which can serve as master regulators of wound healing. The
effect of specific genetic information is also modified a lot by environmental epigenetic
factors. Epigenetic changes have been shown to control the wound healing outcomes.

Inclusion Criteria:

- Age ≥ 18 years

- Willing to comply with protocol instructions, including all study visits and study
activities.

- Chronic wounds

Exclusion Criteria:

- Pregnant females

- Subjects with marked immunodeficiency (HIV/AIDS)

- Prisoners
We found this trial at
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Indianapolis, Indiana 46202
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Indianapolis, IN
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