Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Before and After Treatment

Inclusion Criteria:

- Children ages 6-17 years of all races/ethnicities with plaque and/or extensive guttate
psoriasis for at least 6 months and on topical or systemic therapy

- Patients in the systemic group can be starting a medication for the first time OR
transitioning from another systemic if unresponsive and on that previous treatment for
≤ 3 months.

- Patients may concurrently have psoriatic arthritis if initiation of a systemic
medication is warranted by skin severity.

- Children ages 6-17 years of all races/ethnicities with acne being treated with
isotretinoin

- Children ages 6-17 years of all races/ethnicities without plaque or guttate psoriasis
and history of severe acne or treatment with isotretinoin as controls.

Exclusion Criteria:

- Patients less than 6 years of age or 18 years and older

- Patients with congenital heart disease, prior cardiac catheterizations/surgeries, or
on cardiac medications in the past two years other than for hypertension (eg, calcium
channel-blockers, beta-blockers and vasotropic medications).

- Patients who have other systemic inflammatory diseases (including atopic dermatitis,
severe acne, inflammatory bowel disease, juvenile idiopathic arthritis, connective
tissue diseases and/or other autoimmune diseases).

- Patients who have active infection or malignancy or have suffered from infection
requiring oral or parenteral antibiotic in past 2 weeks.

- Patients and parents/caregivers unable to give written informed consent.