High Frequency Oscillation in Pediatric Epilepsy Surgery
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | Any - 21 |
| Updated: | 1/2/2019 |
| Start Date: | November 29, 2018 |
| End Date: | December 31, 2022 |
High Frequency Oscillation (HFO) on ElectroCorticoGraphy (ECoG) has been identified as a new
biomarker for epileptogenic tissue. The purpose of this study is to see if epilepsy surgery
guided by the combination of HFO on ECoG and standard clinical practice can result in a
greater likelihood of seizure freedom, versus standard clinical practice alone, without HFOs.
biomarker for epileptogenic tissue. The purpose of this study is to see if epilepsy surgery
guided by the combination of HFO on ECoG and standard clinical practice can result in a
greater likelihood of seizure freedom, versus standard clinical practice alone, without HFOs.
Intra-operative electrocorticography (ECoG), based on interictal spike and spike patterns, is
performed to optimize delineation of the epileptogenic tissue in the operating room during
epilepsy surgery. Similarly, extra-operative electrocorticography is often recorded over days
to weeks with intracranial grids and depth electrodes, when the epileptogenic zone is not
clearly localized with non-invasive studies and/or with intra-operative ECoG. Surgical
resection following extra-operative ECoG is then "tailored' by the seizure onset zone as the
gold standard.
High frequency oscillations have been identified as a more precise biomarker for
epileptogenic tissue. The aim of this double-blind randomized surgical trial is to determine
if HFO- tailored surgery combining HFOs and current standard of care, compared to current
standard of care alone, will lead to a better seizure outcome.
performed to optimize delineation of the epileptogenic tissue in the operating room during
epilepsy surgery. Similarly, extra-operative electrocorticography is often recorded over days
to weeks with intracranial grids and depth electrodes, when the epileptogenic zone is not
clearly localized with non-invasive studies and/or with intra-operative ECoG. Surgical
resection following extra-operative ECoG is then "tailored' by the seizure onset zone as the
gold standard.
High frequency oscillations have been identified as a more precise biomarker for
epileptogenic tissue. The aim of this double-blind randomized surgical trial is to determine
if HFO- tailored surgery combining HFOs and current standard of care, compared to current
standard of care alone, will lead to a better seizure outcome.
Inclusion Criteria:
- Age 0-21 years
- Refractory focal epilepsy
- Planned resective epilepsy neurosurgery
- Includes intraoperative or extraoperative electrocorticography with grids
- Planned resective epilepsy surgery approved by institutional surgery board
Exclusion Criteria:
- Subjects undergoing non-resective neurosurgery
- Does not include intraoperative or extraoperative electrocorticography with grids
- Planned resective surgery is a hemispherectomy/hemispherotomy
We found this trial at
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University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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