Metabolic Effects of Sleep Extension in People With Obesity
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 1/2/2019 |
| Start Date: | November 1, 2018 |
| End Date: | July 2023 |
| Contact: | Study Coordinator |
| Email: | bogerz@wustl.edu |
| Phone: | 314-273-1882 |
This study is designed to determine the impact of extending sleep duration on glucose
metabolism in people with obesity. Half of the participants will be instructed to increase
their time-in-bed to 8 hours (sleep extension) while the other half will be be instructed to
maintain their current sleep habits.
metabolism in people with obesity. Half of the participants will be instructed to increase
their time-in-bed to 8 hours (sleep extension) while the other half will be be instructed to
maintain their current sleep habits.
Restricting sleep is known to be detrimental to glucose metabolism in healthy adults. Obesity
is a condition associated with both lower sleep duration and poor glucose tolerance.
Therefore, increasing sleep duration is a potentially novel therapeutic strategy for
improving glucose metabolism in this population. The investigators will assess this by
determining insulin sensitivity during a hyperinsulinemic-euglycemic clamp before and after a
sleep extension intervention in both the control and sleep extension groups.
is a condition associated with both lower sleep duration and poor glucose tolerance.
Therefore, increasing sleep duration is a potentially novel therapeutic strategy for
improving glucose metabolism in this population. The investigators will assess this by
determining insulin sensitivity during a hyperinsulinemic-euglycemic clamp before and after a
sleep extension intervention in both the control and sleep extension groups.
Inclusion Criteria:
- Sleep <6h/night
- Body mass index 30-45 kg/m2
- Altered glucose metabolism (any of the following) Fasting glucose >100 mg/dL or, 2-h
plasma glucose >140 mg/dL during an oral glucose tolerance test (OGTT) or, HbA1c >5.7%
or, homeostatic model assessment of insulin resistance (HOMA-IR) >2.5
Exclusion Criteria:
- Sleep disorders
- Excessive caffeine or alcohol consumption
- Significant organ dysfunction/disease (e.g. diabetes, kidney disease)
- Prior bariatric surgery
- Pregnancy
- Tobacco or illicit drug use
- Perform regular moderate or intense exercise
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-273-1882
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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