Novel Approaches to Reducing Tobacco Related Harm

Participants will sample 4 alternative nicotine/tobacco products and provide initial
reactions to the products.

Inclusion Criteria:

1. HIV-infected adults age 18 and older currently receiving HIV care

2. Self-report smoking ≥10 cigarettes/day of a brand delivering >0.5mg nicotine for >2yrs

3. Have afternoon expired CO concentrations of ≥10ppm or morning urinary cotinine
>100ng/ml (as measured with NicAlert)

Exclusion Criteria:

1. Impaired mental status as assessed by observation

2. Acute intoxication as measured by breath alcohol level (BAL) > 0

3. Current use of nicotine replacement or other pharmacotherapy for smoking cessation

4. Previous use of e-cigarettes

5. Use of other tobacco products (e.g., chew tobacco, cigars) on > 10 of the past 30 days

6. Unstable HIV or associated comorbidities, as determined by a licensed medical
professional.

7. Pregnancy (Females testing positive for pregnancy and any participants wishing to quit
immediately will be referred to community smoking cessation treatment and will be
excluded from the study)

8. Blood pressure at or above 160/100 or below 90/50

9. Heart rate at or above 105 bpm or below 45 bpm