Isometric Exercise and Endogenous Pain Inhibition

Conditions:Fibromyalgia, Pain
Therapuetic Areas:Musculoskeletal, Rheumatology
Age Range:18 - 75
Start Date:May 25, 2018
End Date:August 2022
Contact:Marie Hoeger Bement, PT, PhD

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Isometric Exercise and Endogenous Pain Modulation

The purpose of this study is to identify the acute effects of isometric exercise on the
inhibition of pain in individuals with fibromyalgia.

Fibromyalgia syndrome (FMS) is a chronic pain condition that is characterized by widespread
pain which affects 5-8% of the general population. Past research has shown that people with
FMS demonstrate enhanced pain facilitation and reduced pain inhibition in the central nervous
system. Incorporating a biopsychosocial model of pain may help develop strategies to prevent
the functional decline and alleviate the suffering that occurs in this population. Exercise
is a mainstay of pain rehabilitation with multiple health benefits, one of which is
decreasing pain; a phenomenon known as exercise induced hypoalgesia (EIH). Emerging evidence
has shown that exercise decreases pain facilitation in healthy adults and in some individuals
with FMS. However, it's unclear whether exercise improves pain inhibition in individuals with
FMS. The purpose of this study is to investigate endogenous pain inhibition, measured by
conditioned pain modulation (CPM), following isometric exercise of the quadriceps muscle in
individuals with FMS. In addition, factors that might affect this response such as physical
activity, body composition, and psychosocial issues will be examined. Understanding how
exercise impacts pain and the contributing factors will help guide the prescription of
exercise to optimize pain rehabilitation.

Inclusion Criteria:

- Men and women aged 18-75 diagnosed with fibromyalgia or healthy controls will be
included in the study.

Exclusion Criteria:

- cardiovascular disease, cancer, pregnancy, arthritis, diabetes, claustrophobia,
Reynaud's disease, osteoporosis, neuropathy.
We found this trial at
Milwaukee, Wisconsin 53201
Phone: 414-288-6738
Milwaukee, WI
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