Clinical Research in ALS Study

Therapuetic Areas:Neurology
Age Range:18 - Any
Start Date:February 2005
End Date:December 2027
Contact:Anne-Laure Grignon, MD

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Clinical Research in Amyotrophic Lateral Sclerosis

CRiALS is an umbrella protocol through which people are recruited to participate in a range
of research studies being conducted by the ALS Research Collaboration (ARC).

Research goals include elucidation of the complex relationship between ALS and related
neurodegenerative disorders, development of both wet and dry biomarkers of disease, and
delineation of the full course of the natural history of disease from the early
pre-symptomatic stages through established and even late-stage disease. These goals are
accomplished through the recruitment and evaluation of patients with ALS and related
diseases, family members (including people at genetic risk for ALS, but who are not yet
affected), and healthy controls.

Inclusion Criteria:

1. At least 18 years of age.

2. Member of at least one of the following categories:

1. Individuals affected with ALS or a related neurodegenerative disease (sporadic or

2. Unaffected individuals from fALS pedigrees, including pre-symptomatic individuals
at genetic risk for ALS or individuals from pedigrees of ALS related diseases.

3. Healthy controls

3. Able and willing to comply with relevant procedures.

Exclusion Criteria:

Subject has a condition or is in a situation which, in the PI's opinion, could confound the
study finding or may interfere significantly with the individual's participation and
compliance with the study protocol -- including but not limited to neurological,
psychological and/or medical conditions (e.g., multiple sclerosis, neuropathy, myelopathy).
We found this trial at
Miami, Florida 33124
(305) 284-2211
Phone: 888-413-9315
University of Miami A private research university with more than 15,000 students from around the...
Miami, FL
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