Repeat Quadratus Lumborum Block to Reduce Opioid Need in Patients After Pancreatic Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/13/2019 |
| Start Date: | February 28, 2019 |
| End Date: | December 31, 2019 |
| Contact: | Ching-Wei Tzeng |
| Email: | cdtzeng@mdanderson.org |
| Phone: | 713-792-6940 |
Randomized Controlled Trial of Repeat vs. Single Quadratus Lumborum Block to Reduce Opioid Prescriptions After Open Pancreatectomy ("RESQU-BLOCK" Trial)
This phase II trial studies how an additional anesthetic nerve block, called a quadratus
lumborum block, works to reduce the need for opioids in patients after pancreatic surgery.
Giving an additional regional anesthetic after surgery may hasten the weaning process, reduce
the need for opioid medications upon discharge, and reduce the risk of opioid dependence.
lumborum block, works to reduce the need for opioids in patients after pancreatic surgery.
Giving an additional regional anesthetic after surgery may hasten the weaning process, reduce
the need for opioid medications upon discharge, and reduce the risk of opioid dependence.
PRIMARY OBJECTIVES I. To use a phase II randomized controlled trial to compare the
intervention of a second regional anesthetic block (quadratus lumborum [QL] block) versus
usual care (single intraoperative QL block) to increase the proportion of opioid-free
pancreatic cancer survivors at discharge after potentially curative surgery.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM 1: Patients undergo QL block before surgery and receive standard of care multimodal pain
control after surgery.
ARM 2: Patients undergo QL block before surgery and receive multimodal pain control. Patients
then undergo a second QL block on day 4 after surgery and continue to receive standard of
care.
After completion of study treatment, patients are followed up at 1 week, every 2 weeks for 8
weeks, and then every 3 months for up to 1 year.
intervention of a second regional anesthetic block (quadratus lumborum [QL] block) versus
usual care (single intraoperative QL block) to increase the proportion of opioid-free
pancreatic cancer survivors at discharge after potentially curative surgery.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM 1: Patients undergo QL block before surgery and receive standard of care multimodal pain
control after surgery.
ARM 2: Patients undergo QL block before surgery and receive multimodal pain control. Patients
then undergo a second QL block on day 4 after surgery and continue to receive standard of
care.
After completion of study treatment, patients are followed up at 1 week, every 2 weeks for 8
weeks, and then every 3 months for up to 1 year.
Inclusion Criteria:
- Adult patients undergoing elective open pancreatic resection for potentially curative
intent (pancreaticoduodenectomy or distal pancreatectomy) who would otherwise be
treated with QL block + IV-PCA converted to oral pain meds (non-narcotic bundle +
opioid pain pill).
Exclusion Criteria:
- Patients with current or past substance (drug or alcohol) abuse disorder.
- Laparoscopic or minimally invasive surgery.
We found this trial at
1
site
Houston, Texas 77030
Principal Investigator: Ching-Wei D. Tzeng
Phone: 713-792-6940
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