Safety, Tolerability and Pharmacokinetics of 14-day Multiple Dose Titrations of TS-134 in Healthy Volunteers

Inclusion Criteria:

- Healthy adult male and female participants between 18 and 55 years of age

- Body weight greater than or equal to 45 kg

- Body Mass Index (BMI) greater than or equal to 18 and less than or equal to 30 kg/m^2

Exclusion Criteria:

- Female participants who are pregnant, intend to become pregnant, or are breastfeeding

- Clinically significant abnormal physical examination, 12-lead electrocardiogram (ECG)
OR cardiac telemetry prior to dosing.

- Significant history or presence of hepatic, renal, cardiovascular, pulmonary,
gastrointestinal, hematological, locomotor, immunologic, ophthalmologic, metabolic or
oncological disease.

- History or presence of psychiatric or neurologic disease or condition

- History of alcohol or drug abuse

- Any participant who currently uses or has used tobacco or tobacco-containing products
for at least one month prior to screening

- Participated in strenuous exercise within 48 hours prior to study start (initial
dosing) and/or are unwilling to avoid strenuous exercise at any time throughout the
study.