A Study of Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)



Status:Completed
Conditions:Neurology, Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 64
Updated:11/17/2018
Start Date:April 2009
End Date:June 2012

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Multiple Subcutaneous Doses of LY2127399, an Anti-BAFF Human Antibody, in Subjects With Relapsing-Remitting Multiple Sclerosis

To look at the ability of LY2127399 to reduce magnetic resonance imaging (MRI) lesions at 12,
16, 20, and 24 weeks compared to placebo.


Inclusion Criteria:

- 18 through 64 years of age diagnosed with RRMS, who can walk without aid or rest for
at least 200 meters (approximately 1/10 of a mile).

- Women who can become pregnant must use birth control.

Exclusion Criteria:

- Have had a live vaccination within 12 weeks before randomization, or intend to have a
live vaccination during the course of the study.

- Have had had recent surgery or are scheduled to have surgery during the study.

- Are immunocompromised or have evidence of active infection [such as hepatitis,
tuberculosis or, human immunodeficiency virus (HIV)].

- Have been on certain drugs that are being studied for RRMS or have recently received
prescription drugs to treat RRMS.

- Have had a recent serious infection.

- Have serious or uncontrolled illnesses other than RRMS.

- Have clinically significant blood test values.

- Have multiple or severe drug allergies.

- Have contraindications for MRI "scanning" or claustrophobia (fear of an enclosed
space) that cannot be managed.
We found this trial at
28
sites
898
mi
from
Akron, OH
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1481
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from
Biddeford, ME
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Charlotte, North Carolina 28207
959
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Charlotte, NC
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409
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Denver, CO
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Farmington Hills, Michigan 48334
829
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Farmington Hills, MI
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622
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Franklin, TN
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1153
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Fullerton, CA
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?
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Green, OH
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994
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Greensburg, PA
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Greenville, South Carolina 29605
882
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from
Greenville, SC
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643
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from
Indianapolis, IN
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196
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Kansas City, KS
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725
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from
Lexington, KY
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368
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from
Lubbock, TX
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467
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Memphis, TN
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1231
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from
Naples, FL
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1170
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Newport News, VA
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378
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from
Northbrook, IL
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853
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from
Phoenix, AZ
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1304
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from
Plantation, FL
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1064
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from
Raleigh, NC
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979
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from
Roanoke, VA
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499
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from
Round Rock, TX
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1143
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from
Sarasota, FL
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1301
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from
Schenectady, NY
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5763
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from
Sofia,
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1276
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from
Toms River, NJ
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833
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from
Tucson, AZ
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