Resistance Exercise to Improve Flu Vaccine for Older Adults
| Status: | Recruiting |
|---|---|
| Conditions: | Influenza |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 11/18/2018 |
| Start Date: | October 8, 2018 |
| End Date: | December 1, 2019 |
| Contact: | Emily C LaVoy, PhD |
| Email: | eclavoy@uh.edu |
| Phone: | 713-743-0829 |
Resistance Exercise to Improve Vaccine Outcomes in Older Adults
This study evaluates whether resistance exercise will improve immune responses to the
seasonal influenza vaccine in older adults. One third of the participants will perform
exercise in the arm that receives the vaccine, one third of the participants will perform the
same exercise in the arm that does not receive the vaccine, and one third will only receive
the vaccine.
seasonal influenza vaccine in older adults. One third of the participants will perform
exercise in the arm that receives the vaccine, one third of the participants will perform the
same exercise in the arm that does not receive the vaccine, and one third will only receive
the vaccine.
Resistance exercise, particularly novel eccentric exercise, recruits immune cells to the
targeted muscle. The exercises selected here targets the deltoid and biceps brachii
muscles-those same muscles that the flu vaccine is delivered to during typical vaccination.
targeted muscle. The exercises selected here targets the deltoid and biceps brachii
muscles-those same muscles that the flu vaccine is delivered to during typical vaccination.
Inclusion Criteria:
- non-frail older adult (≥65 years old) of any sex and race/ethnicity
- non-smokers (>10 yrs)
- meets American College of Sports Medicine criteria for participation in exercise
- US resident
Exclusion Criteria:
- underlying medical problems that contraindicate supervised resistance exercise
- past or present history of autoimmune disease, HIV, hepatitis, stroke, or
cardiovascular disease
- current debilitating arthritis of the shoulder
- central or peripheral nervous disorders
- bedridden in the past three months
- history of vaccine-related allergies, or severe egg allergy;
- physician-confirmed influenza infection in the prior year
- regular user of corticosteroids
- functional or cognitive impairment that would limit exercise performance or prohibit
informed consent
- blood pressure greater than 160/90
- participation in resistance arm exercises in the prior 6 months
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