To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis).



Status:Recruiting
Conditions:Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:2/27/2019
Start Date:October 31, 2018
End Date:October 2019
Contact:Nikhil Sawant
Email:nikhil.sawant@glenmarkpharma.com
Phone:91 22 6138 3131

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A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multiple-Site Study to Evaluate the Therapeutic Equivalence of a Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064% (Glenmark Pharmaceuticals Ltd) to the Marketed Product Enstilar® Foam (LEO Pharma Inc.) in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis)

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multiple-Site
Study to Evaluate the Therapeutic Equivalence of a Generic Calcipotriene and Betamethasone
Dipropionate Topical Foam, 0.005%/0.064% (Glenmark Pharmaceuticals Ltd) to the Marketed
Product Enstilar® Foam (LEO Pharma Inc.) in the Treatment of Psoriasis Vulgaris (Plaque
Psoriasis)


Inclusion Criteria:

1. Male or non-pregnant, non-lactating female subjects aged at least 18 years at Visit 1.

2. A clinical diagnosis of stable (at least 6 months) psoriasis vulgaris involving 5% to
30% body surface area (BSA), not including the face, axilla and groin.

3. A PGA of disease severity of at least moderate disease severity (Grade ≥ 3).

4. A plaque elevation of at least moderate severity (Grade ≥ 3) at the target lesion
site. The most severe lesion at baseline should be identified as the target lesion.

5. Provide written informed consent. -

Exclusion Criteria:

1. Current diagnosis of unstable forms of psoriasis in the treatment area including
guttate, erythrodermic, exfoliative, or pustular psoriasis.

2. Other inflammatory skin disease in the treatment area that may confound the evaluation
of the psoriasis vulgaris (e.g., atopic dermatitis, contact dermatitis, tinea
corporis).

3. Presence of pigmentation, extensive scarring, pigmented lesions, or sunburn in the
treatment areas that could interfere with the rating of efficacy parameters.

4. History of psoriasis unresponsive to topical treatments.

5. History of hypersensitivity to any component of the Test or Reference product.

6. Current or past history of hypercalcemia, calcium metabolism disorder, vitamin D
toxicity, severe renal insufficiency, or severe hepatic disorders.

7. Current immunosuppression.

8. Use within 6 months prior to baseline of biologic treatment for psoriasis (e.g.,
infliximab, adalimumab, alefacept).

9. Use within 3 months prior to baseline of: 1) chemotherapy or 2) radiation therapy.

10. Use within 2 months prior to baseline of: 1) immunosuppressive drugs (e.g.,
tacrolimus, pimecrolimus) or 2) oral retinoids.

11. Use within 1 month prior to baseline of: 1) systemic steroids, 2) systemic
antibiotics, 3) other systemic antipsoriatic treatment, 4) psoralen and ultraviolet A
(PUVA) therapy, 5) ultraviolet B (UVB) therapy, or 6) systemic anti-inflammatory
agents. Note: a) Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin use on an
as-needed basis and if not used consecutively for > 14 days prior to baseline and/or
during the study is acceptable. Low-dose (81 mg) aspirin taken daily is acceptable. b)
Intranasal or inhaled corticosteroids are acceptable if kept constant throughout the
study. Intra-articular steroid injections are permissible.

12. Use within 2 weeks prior to baseline of: 1) topical antipsoriatic drugs (e.g.,
salicylic acid, anthralin, coal tar, calcipotriene, tazarotene), 2) topical
corticosteroids, or 3) topical retinoids.

13. Use within 2 weeks prior to baseline of: 1) vitamin D supplements 2) vitamin D analogs
at a dose >400 IU/day; or 3) calcium supplements (including multivitamins containing
calcium).

14. Started beta-blocker therapy, antimalarial products, and/or lithium within 3 months of
baseline. Subjects who have been on a steady dose for at least 3 months prior to
baseline and will remain on the same dose throughout the study are eligible for study
participation.

15. Subjects with planned phototherapy and/or exposure to ultraviolet A (UVA) and/or UVB
during the study.
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