A Dose Escalation Study of Bradanicline in Refractory Chronic Cough



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - 80
Updated:2/17/2019
Start Date:November 5, 2018
End Date:October 2019
Contact:Medical Director
Email:info@attenua.com
Phone:650-490-4004

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A Dose Escalation Study to Assess the Efficacy and Safety of Bradanicline in Subjects With Refractory Chronic Cough

This is a randomized, double-blind, placebo-controlled, crossover, dose escalation study of
bradanicline in subjects with chronic cough

This study will have two 21-day treatment periods separated by a 14-day washout period. There
will be a 14-day follow-up period.

Inclusion Criteria:

- Chest radiograph or computed tomography (CT) scan of the thorax within the last 1 year
not demonstrating any abnormality considered to be significantly contributing to the
refractory chronic cough

- Diagnosis of refractory chronic cough or unexplained cough for at least one year

- Women of child-bearing potential who use 2 forms of acceptable birth control method

- Male subjects and their partners of child-bearing potential who use 2 methods of
acceptable birth control

- Has provided written informed consent

Exclusion Criteria:

- Current smoker (cigarettes or e-cigarettes) or has given up smoking within the past 12
months

- Currently taking an ACE-inhibitor or requiring treatment with an ACE-inhibitor during
the study or within 12 weeks prior to the Baseline Visit

- Has an upper or lower respiratory tract infection or recent significant change in
pulmonary status within 4 weeks of the Baseline Visit

- Has a history of cystic fibrosis

- Has a history of malignancy within 5 years prior to the Baseline Visit

- Has active hepatitis infection

- Has a history of human immunodeficiency virus (HIV) infection

- Has a positive test for any drug of abuse

- Has a history of hypersensitivity to bradanicline or any of its components
We found this trial at
17
sites
Plymouth, Minnesota 55441
Phone: 763-744-1140
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4410 Medical Drive
San Antonio, Texas 78229
210-692-7157
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San Antonio, TX
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Bellingham, Washington 98225
Phone: 360-733-5733
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Bellingham, WA
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Colorado Springs, Colorado 80907
Phone: 719-473-0872
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Colorado Springs, CO
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Colorado Springs, Colorado 80907
Phone: 719-955-6000
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Colorado Springs, CO
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Dallas, Texas 75231
Phone: 214-365-0365
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Dallas, TX
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Dallas, Texas 75231
Phone: 214-361-5555
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Dallas, TX
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Denver, Colorado 80230
Phone: 720-858-7510
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Denver, CO
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Gastonia, North Carolina 28054
Phone: 704-675-7144
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Gastonia, NC
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Greenfield, Wisconsin 53228
Phone: 414-529-8519
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Greenfield, WI
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La Mesa, California 91942
Phone: 619-637-0770
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La Mesa, CA
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Largo, Florida 33872
Phone: 727-397-8557
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Largo, FL
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Mission Viejo, California 92691
Phone: 949-347-8700
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Mission Viejo, CA
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North Charleston, South Carolina 29420
Phone: 843-820-1036
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North Charleston, SC
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Ocean Township, New Jersey 07712
Phone: 732-695-2555
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Ocean Township, NJ
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Rochester, Minnesota 55905
Phone: 507-284-2158
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Rochester, MN
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Winter Park, Florida 32789
Phone: 407-740-8078
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Winter Park, FL
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