Spontaneous Regression in Metastatic Melanoma and Renal Cell Carcinoma

Spontaneous regression in patients with metastatic cancer is an incredibly rare event. It has
been described after infection in cancer patients and also rarely in patients with renal cell
cancer (usually after resection of the renal primary) and, less commonly, in patients with
metastatic melanoma.

Primary Objective To collect peripheral blood from patients with metastatic melanoma and
renal cell cancer and spontaneous regression for studies of immune response and other
studies.

Secondary Objective To collect clinical data from subjects registered to this study. Clinical
data collection will include demographics and cancer characteristics, history and treatment.

Inclusion Criteria

1. ≥ 18 years old at the time of informed consent

2. Ability to provide written informed consent and HIPAA authorization

3. Patients must have metastatic melanoma or renal cell cancer with spontaneous
regression.

4. Willingness to undergo phlebotomy for research blood samples

Exclusion Criteria

1. Concurrent disease or condition that would make the patient inappropriate for study
participation or any serious medical or psychiatric disorder that would interfere with
the subject's safety

2. Dementia, altered mental status, or any psychiatric condition that would prohibit the
understanding or rendering of informed consent