A Cohort Study of the Intestinal Microbiota of Premature Infants
| Status: | Recruiting |
|---|---|
| Conditions: | Bronchitis, Colitis, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/25/2019 |
| Start Date: | December 23, 2018 |
| End Date: | December 2026 |
| Contact: | Mark Underwood, MD |
| Email: | munderwood@ucdavis.edu |
| Phone: | 916-703-3050 |
Premature infants are at risk for a variety of diseases, the investigators would like to
learn more about why some premature babies are at higher risk and some are protected from
these diseases.
Scientists at UC Davis and other universities have developed new ways to measure the bacteria
and a large number of small molecules in specimens of infant blood, urine, stomach fluid and
poop and in mother's milk. These discoveries allow us to consider questions that were
impossible to answer before these new techniques were developed. One such question is whether
the bacteria in the poop of a premature baby can help us predict the baby's risk for
developing infection or a common and serious disease of premature infants called necrotizing
enterocolitis. A second question is whether the DNA of a premature baby (obtained from saliva
with a q-tip) can predict higher risk for diseases of premature babies.
learn more about why some premature babies are at higher risk and some are protected from
these diseases.
Scientists at UC Davis and other universities have developed new ways to measure the bacteria
and a large number of small molecules in specimens of infant blood, urine, stomach fluid and
poop and in mother's milk. These discoveries allow us to consider questions that were
impossible to answer before these new techniques were developed. One such question is whether
the bacteria in the poop of a premature baby can help us predict the baby's risk for
developing infection or a common and serious disease of premature infants called necrotizing
enterocolitis. A second question is whether the DNA of a premature baby (obtained from saliva
with a q-tip) can predict higher risk for diseases of premature babies.
Samples from eligible infants will be collected and stored for future comparisons. These
samples include stool specimens from a messy diaper twice weekly, urine samples from cotton
balls in the diaper once weekly, a small sample of stomach fluid once a week just prior to a
feeding obtained through the feeding tube, a sample of mom's milk once a week, left-over
blood from lab draws, and a sample of saliva on one occasion.
The analysis of key specimens from this cohort will allow us to study the impact of the
bacteria in the intestines on outcomes like growth and common diseases of premature infants.
samples include stool specimens from a messy diaper twice weekly, urine samples from cotton
balls in the diaper once weekly, a small sample of stomach fluid once a week just prior to a
feeding obtained through the feeding tube, a sample of mom's milk once a week, left-over
blood from lab draws, and a sample of saliva on one occasion.
The analysis of key specimens from this cohort will allow us to study the impact of the
bacteria in the intestines on outcomes like growth and common diseases of premature infants.
Inclusion Criteria:
- gestational age < 33 weeks at birth
Exclusion Criteria:
We found this trial at
1
site
Click here to add this to my saved trials
