Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 10/20/2018 |
| Start Date: | September 2007 |
| End Date: | March 15, 2011 |
Determine the in-vivo mechanism of action of INF-B-1b as it's mechanisms of action are not
completely understood. We propose that high dose exogenous recombinant IFN-B-1b induces
tolerizing effect on DC-dependent T-cell differentiation in patients with MS by inducing the
expression of SOCS3 in DCs.
completely understood. We propose that high dose exogenous recombinant IFN-B-1b induces
tolerizing effect on DC-dependent T-cell differentiation in patients with MS by inducing the
expression of SOCS3 in DCs.
Inclusion Criteria:
- Confirmed diagnosis of MS
- Age 18-60 years, inclusive
- Expanded disability status of 0-6.5
- Give written informed consent prior to any testing under this protocol
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