Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer

PRIMARY OBJECTIVES:

I. To estimate the diagnostic performance as quantified by the area under the ROC curve to
detect aggressive prostate cancer.

II. To develop a risk prediction model by incorporating overall PI-RADS, PSA, Gleason score
and clinical stage to predict the presence of aggressive prostate cancer.

SECONDARY OBJECTIVES:

I. To evaluate the diagnostic performance of the individual PI-RADS score of each MRI
parameter (T2W, DWI and DCE), as determined by local imaging review.

TERTIARY OBJECTIVES:

I. All clinical data including magnetic resonance (MR) images will be banked for future
exploratory research aims.

OUTLINE:

Patients undergo mpMRI within 3 months prior to schedule surgery.

After completion of study, patients are followed up until radical prostatectomy pathology is
reported and finalized.

Inclusion Criteria:

- Recently diagnosed with prostate cancer for whom definitive surgical treatment is
indicated

Exclusion Criteria:

- Not suitable to undergo MRI or receive gadolinium-based contrast agent (severe,
untreatable claustrophobia; MRI-incompatible metallic objects or implanted medical
devices; renal failure; weight greater than allowable by scanner per institutional
standard practice)

- Prior surgical and/or non-surgical treatment for prostate cancer

- Prior hip replacement or other major pelvic surgery