Quality of Life Assessment in Patients Receiving Cryotherapy and Chemotherapy for Unresectable Esophageal or Gastroesophageal Cancer

Inclusion Criteria:

- Has esophageal or gastroesophageal cancer and will be receiving chemotherapy

- Dysphagia score of 1, 2, 3 or 4.

- Age ≥18 years old

- American Society of Anesthesiologists (ASA) Physical Status Classification ≤ 4

- Deemed not a candidate for esophageal cancer surgical resection

- Female subjects must be either post-menopausal, surgically sterilized, or willing to
use an acceptable method of birth control (i.e., total abstinence, birth control
pills, an intrauterine device (IUD), diaphragm, progesterone injections or implants,
or condoms plus a spermicide) for the duration of the study

Exclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status greater than 2

- Patient who received radiation treatment in the prior 8 weeks

- Known brain metastases causing cranial nerve deficits which can cause dysphagia

- Inability to undergo an esophagogastroduodenoscopy (EGD)

- Pregnant or nursing

- Surgery or anatomy where capacity of stomach is reduced making cryotherapy
contraindicated

- Patients with tracheoesophageal fistula