Smoking Relapse Prevention Via Just-in-Time-Adaptive Interventions
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Smoking Cessation |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/10/2019 |
| Start Date: | April 1, 2019 |
| End Date: | January 30, 2022 |
| Contact: | Bryan W Heckman, PhD |
| Email: | heckmanb@musc.edu |
| Phone: | 717-951-1275 |
Personalized Smoking Relapse Prevention Delivered in Real-Time Via Just-in-Time-Adaptive Interventions
A small-scale randomized controlled trial (RCT) will pilot test a personalized JITAI designed
to guide delivery of fast acting nicotine replacement therapy (NRT; lozenge) in real-time, to
prevent smoking relapse. Specifically, a smartphone application (app), will integrate
pre-quit smoking data with objective location data captured via global positioning system
(GPS) to establish relapse risk (hotspot) algorithms. During a quit attempt, the GPS-enabled
app (QuitBuddy) will detect proximity to hotspots and deliver NRT prompts, all of which will
occur automatically and prior to exposure. Thus, QuitBuddy will optimize NRT use to prevent
cue-provoked cravings known to undermine sustained abstinence, thereby repurposing this
evidence-based cessation medication to promote relapse prevention. QuitBuddy will be tested
against standard care (NRT with brief instructions). Two versions of QuitBuddy will be
tested, which will differ only in how hotspot algorithms are derived: retrospectively from
locations recalled at the onset of a quit attempt (QuitBuddy-Recall) or based on real-time
EMA completed pre-quit (QuitBuddy).
to guide delivery of fast acting nicotine replacement therapy (NRT; lozenge) in real-time, to
prevent smoking relapse. Specifically, a smartphone application (app), will integrate
pre-quit smoking data with objective location data captured via global positioning system
(GPS) to establish relapse risk (hotspot) algorithms. During a quit attempt, the GPS-enabled
app (QuitBuddy) will detect proximity to hotspots and deliver NRT prompts, all of which will
occur automatically and prior to exposure. Thus, QuitBuddy will optimize NRT use to prevent
cue-provoked cravings known to undermine sustained abstinence, thereby repurposing this
evidence-based cessation medication to promote relapse prevention. QuitBuddy will be tested
against standard care (NRT with brief instructions). Two versions of QuitBuddy will be
tested, which will differ only in how hotspot algorithms are derived: retrospectively from
locations recalled at the onset of a quit attempt (QuitBuddy-Recall) or based on real-time
EMA completed pre-quit (QuitBuddy).
Inclusion Criteria:
- at least 18 years of age
- daily cigarette smoker of > 9 cigarettes/day for past year
- CO breath monitor detects > 10ppm
- literate in English
- willing to make a quit attempt in the next week with nicotine replacement therapy
- no plans to travel outside of a 100-mile radius of Charleston during the study
Exclusion Criteria:
- FDA contraindications for use of NRT:
1. Pregnant
2. Breastfeeding or planning to become pregnant
3. Recent (past 3 months) cardiovascular trauma: MI, stroke
- current use (past 30 days) of alternative tobacco products or smoking cessation
medications
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