Imaging of in Vivo Sigma-2 Receptor Expression With 18F-ISO-1 Positron Emission Tomography in Metastatic Breast Cancer



Status:Recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:10/3/2018
Start Date:April 5, 2016
End Date:April 5, 2020
Contact:Elizabeth McDonald, MD, Ph.D
Email:PennCancerTrials@emergingmed.com
Phone:855-216-0098

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Pilot study using [18F]ISO-1 PET/CT to image sigma-2 receptor binding in metastatic breast
cancer. Correlate baseline uptake and change in uptake after therapy with time to progression
and standard and experimental pathology assays of biopsy or surgical tissue. The target
population is up to 30 adult patients at least 18 years, with at least one site of disease
outside the liver by at least one type of standard imaging.


Inclusion Criteria:

- At least 18 years of age

- Biopsy proven or clinically documented metastatic breast cancer with at least one
lesion outside the liver by standard imaging (e.g. CT, MRI, Bone Scan, Ultrasound, FDG
PET/CT)

- Plan to start new systemic therapy for metastatic disease.

- Participants must be informed of the investigational nature of this study and be
willing to provide written informed consent and participate in this study in
accordance with institutional and federal guidelines prior to study-specific
procedures.

Exclusion Criteria:

- Females who are pregnant at the time of screening will not be eligible for this study,
urine or serum pregnancy test will be performed in women of child-bearing potential at
the time of screening.

- Inability to tolerate imaging procedure in the opinion of an investigator or treating
physician.

- Serious or unstable medical or psychological conditions that, in the opinion of the
investigator, would compromise the subject's safety or successful participation in the
study.
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
(215) 662-6065
Phone: 855-216-0098
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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mi
from
Philadelphia, PA
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