JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
| Status: | Not yet recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/26/2018 |
| Start Date: | December 1, 2018 |
| End Date: | December 1, 2021 |
A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
We intend, with this study, to prove that blocking the molecular mechanisms whose blockade
prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We
believe that this evidence will serve as the required basis for proceeding with large,
ICU-based clinical trial(s) of a drug to prevent VIDD.
prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We
believe that this evidence will serve as the required basis for proceeding with large,
ICU-based clinical trial(s) of a drug to prevent VIDD.
Inclusion Criteria:
- Patients undergoing esophagectomy
Exclusion Criteria:
- Patients with more than mild pulmonary dysfunction
- Patients with any neuromuscular disease that might compromise diaphragm function
- Patients with abnormal liver or kidney function
- Patients taking antifungal medications
- History of tuberculosis
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