The Effect of Tranexamic Acid on Blood Loss and Transfusion Requirements Following Open Femur Fracture Surgery
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Orthopedic, Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/22/2018 |
| Start Date: | December 1, 2018 |
| End Date: | December 1, 2019 |
| Contact: | Stephen J Warner, MD, PhD |
| Email: | Stephen.J.Warner@uth.tmc.edu |
| Phone: | 713-500-6261 |
The purpose of this study is to determine the effect of tranexamic acid (TXA) on blood loss
and transfusion requirements in patients with femur fractures requiring open surgical
approaches.
and transfusion requirements in patients with femur fractures requiring open surgical
approaches.
Inclusion Criteria:
- Patients admitted to Memorial Hermann Medical Center with acute femur fractures that
require open surgical approaches for fracture reduction and implant application,
including patients with subtrochanteric, high-energy intertrochanteric,
periprosthetic, and intra-articular distal femur fractures.
Exclusion Criteria:
- Preoperative use of any anticoagulant
- History of deep venous thrombosis or pulmonary embolus
- Allergy to TXA
- Hepatic dysfunction (AST/ALT > 60)
- Renal dysfunction (Cr > 1.5 or GFR < 30)
- History of cerebrovascular accident in the past 12 months
- Active coronary artery disease (event in the past 12 months)
- Presence of drug-eluting stent
- Color blindness
- Presence of an additional acute injury that could contribute to blood transfusion
requirements
We found this trial at
1
site
7000 Fannin St
Houston, Texas 77030
Houston, Texas 77030
(713) 500-4472
Phone: 713-500-6261
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
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