C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions



Status:Recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 99
Updated:9/19/2018
Start Date:July 1, 2017
End Date:May 1, 2022
Contact:Gemma Gliori, MS
Email:ggliori@uwhealth.org
Phone:608-262-7269

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C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions Evaluating Predictability and Accuracy for the Treatment of Acute Cerebral Ischemia in the Angiography Suite

The overarching objective of our proposal is to develop a One-Stop-Shop imaging using the
available C-arm Cone-Beam Computed Tomography (CBCT) data acquisition systems currently
widely available worldwide in interventional angiography suites to enable acute ischemic
stroke patients to be imaged, triaged, treated, and assessed using a single modality in one
room.

This is an evaluation to determine the efficacy of the use of C-arm CBCT with SMART RECON
novel software for the rapid assessment of time-resolved CTA and CT perfusion in the setting
of ischemic cerebrovascular events. As a leading center for the treatment of cerebrovascular
disease in the Midwest as well as being one of the first Comprehensive Stroke Centers in the
United States we have a large potential patient group to assess. Our pilot plan is to compare
conventional CT/CTA/CTP acquired during the clinical work up with C-arm CBCT/CTA/CTP acquired
in the angiography suite at initiation of therapy. The C-arm CBCT acquisition provides whole
brain coverage (compared to only 8 cm brain coverage with conventional CT) with less
radiation and higher resolution; the CT perfusion maps obtained using C-arm CBCT and new
reconstruction algorithms provides better perfusion maps.

Inclusion Criteria:

1. Patients with acute ischemic stroke presenting within 8 hours of onset

2. Patients that present with a large artery occlusion

3. Adults 18 years of age or older.

4. Women of childbearing potential must not be pregnant.

5. National Institutes of Health Stroke Scale (NIHSS) of >5

6. No severe co-morbidities

Exclusion Criteria:

1. Women that are pregnant

2. History of severe renal disease (e.g. stage 4-5)

3. History of renal transplant
We found this trial at
1
site
Madison, Wisconsin 53706
(608) 263-2400
Phone: 608-262-7269
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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