Genetic Basis of Rosacea
| Status: | Recruiting |
|---|---|
| Conditions: | Cosmetic |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/19/2018 |
| Start Date: | May 2015 |
| End Date: | September 2019 |
| Contact: | Anne Chang, MD |
| Email: | alschang@stanford.edu |
| Phone: | 650-721-7151 |
Validation of Candidate Rosacea Genes By Targeted Interrogation of Alleles and Assessment of Rosacea Co-morbidities
Rosacea is a common disease characterized by inflammation and vascular abnormalities of the
facial skin and ocular surface. The exact pathogenesis of papulopustular rosacea is not well
understood and current methods to treat this disease are often unsatisfactory. The purpose of
this study is to develop gene expression profiles of papulopustular rosacea compared to those
of normal skin. The investigators hope to better understand the abnormal gene functions that
might contribute to this condition. This understanding may lead to the development of
additional and better treatments for rosacea.
facial skin and ocular surface. The exact pathogenesis of papulopustular rosacea is not well
understood and current methods to treat this disease are often unsatisfactory. The purpose of
this study is to develop gene expression profiles of papulopustular rosacea compared to those
of normal skin. The investigators hope to better understand the abnormal gene functions that
might contribute to this condition. This understanding may lead to the development of
additional and better treatments for rosacea.
Eligibility Criteria for Rosacea Group:
Inclusion criteria for rosacea participants:
1. Clinical signs and symptoms of rosacea (papulopustular or erythrotelangiectatic
subtypes) present at enrollment as determined by the investigator
2. All four grandparents of European descent
3. Fitzpatrick skin type I or II
4. Age 18 years or older
Exclusion criteria for rosacea participants:
1. Unable or unwilling to provide written informed consent
2. Concomitant facial or medical condition that obscures diagnosis of rosacea (such as
malar erythema from lupus erythematosus)
3. Acne vulgaris
4. Unable or unwilling to provide peripheral blood sample (a few teaspoons)
5. Inability for investigator to verify rosacea diagnosis on clinical examination due to
rosacea treatment(s) leading to complete lack of signs and symptoms (such prior laser
treatments, systemic tetracycline usage, etc.)
6. Use of topical prescription medications or procedures to the face within one month of
enrollment
7. Women who are pregnant or lactating
Eligibility Criteria for Non-Rosacea Group:
Inclusion criteria for control participants:
1. No history of rosacea
2. No clinical signs or symptoms of rosacea
3. No family history of rosacea
4. All four grandparents of European descent
5. Fitzpatrick skin type I or II
6. Age 18 years or older
Exclusion criteria for control participants:
1. Unable or unwilling to provide written informed consent
2. Acne vulgaris
3. Unable or unwilling to provide peripheral blood sample (a few teaspoons)
4. Women who are pregnant or lactating
5. Use of topical prescription medications or procedures to the face within one month of
enrollment
6. Skin conditions that might interfere with interpretation of procedure results (at the
discretion of the investigator)
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