Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)



Status:Enrolling by invitation
Conditions:Depression, Depression, Major Depression Disorder (MDD)
Therapuetic Areas:Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 75
Updated:12/19/2018
Start Date:August 23, 2018
End Date:March 15, 2021

Use our guide to learn which trials are right for you!

An Open-label, Long-term Extended Access Protocol for Rapastinel as Adjunctive or Monotherapy Treatment in Patients With Major Depressive Disorder

Multicenter, open-label, long-term extended access treatment protocol in adult patients with
a primary diagnosis of MDD.


Inclusion Criteria:

- Completion of lead-in study

- Adequate therapeutic benefit in the lead-in study to justify continuation of treatment
with rapastinel in the judgement of the investigator

Exclusion Criteria:

- Suicide risk, as determined by meeting any of the following criteria:

1. A suicide attempt within the past year

2. Significant risk, as judged by the investigator, based on the psychiatric
interview or information collected in the Columbia- Suicide Severity Rating Scale
(C-SSRS) at any visit in the lead-in study

3. Montgomery-Asberg Depression Rating Scale (MADRS) Item 10 score ≥ 5 at any visit
during participation in the lead-in study where MADRS was conducted.

- At imminent risk of injuring self or others or causing significant damage to property,
as judged by the investigator

- Females who are pregnant, breastfeeding, or planning to become pregnant or breastfeed
during participation

- Females of childbearing potential and male partners of females of childbearing
potential, not using a reliable means of contraception
We found this trial at
74
sites
Orange City, Florida 32763
?
mi
from
Orange City, FL
Click here to add this to my saved trials
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
2417 Marshall Ave.
Imperial, California 92251
760-355-0176
?
mi
from
Imperial, CA
Click here to add this to my saved trials
7940 Floyd Curl Dr.
San Antonio, Texas 78229
210-949-0122
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Albuquerque, New Mexico 87109
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Allentown, Pennsylvania 18104
?
mi
from
Allentown, PA
Click here to add this to my saved trials
?
mi
from
Anaheim, CA
Click here to add this to my saved trials
3015 Flowers Road South
Atlanta, Georgia 30341
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Austin, Texas 78737
?
mi
from
Austin, TX
Click here to add this to my saved trials
Austin, Texas 78754
?
mi
from
Austin, TX
Click here to add this to my saved trials
2026 Wirt Road
Bellaire, Texas 77401
?
mi
from
Bellaire, TX
Click here to add this to my saved trials
Bradenton, Florida
?
mi
from
Bradenton, FL
Click here to add this to my saved trials
Brooklyn, New York 11235
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Charleston, South Carolina 29405
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlottesville, Virginia 22903
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
Cincinnati, Ohio 45242
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Costa Mesa, California 92626
?
mi
from
Costa Mesa, CA
Click here to add this to my saved trials
Culver City, California 90230
?
mi
from
Culver City, CA
Click here to add this to my saved trials
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Decatur, Georgia 30030
?
mi
from
Decatur, GA
Click here to add this to my saved trials
Dothan, Alabama 36303
?
mi
from
Dothan, AL
Click here to add this to my saved trials
Encino, California 91316
?
mi
from
Encino, CA
Click here to add this to my saved trials
Flowood, Mississippi 39232
?
mi
from
Flowood, MS
Click here to add this to my saved trials
Fort Myers, Florida 33912
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
200 West Magnolia Avenue
Fort Worth, Texas 76104
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Glendale, California 91204
?
mi
from
Glendale, CA
Click here to add this to my saved trials
Hialeah, Florida 33012
?
mi
from
Hialeah, FL
Click here to add this to my saved trials
Hoffman Estates, Illinois 60169
?
mi
from
Hoffman Estates, IL
Click here to add this to my saved trials
Houston, Texas 17115
?
mi
from
Houston, TX
Click here to add this to my saved trials
1002 Gemini Avenue
Houston, Texas 77058
?
mi
from
Houston, TX
Click here to add this to my saved trials
Irvine, California 92618
?
mi
from
Irvine, CA
Click here to add this to my saved trials
Lake Charles, Louisiana 70601
?
mi
from
Lake Charles, LA
Click here to add this to my saved trials
Lakeland, Florida 33805
?
mi
from
Lakeland, FL
Click here to add this to my saved trials
Lauderhill, Florida 33319
?
mi
from
Lauderhill, FL
Click here to add this to my saved trials
Lemon Grove, California 91945
?
mi
from
Lemon Grove, CA
Click here to add this to my saved trials
Libertyville, Illinois 60048
?
mi
from
Libertyville, IL
Click here to add this to my saved trials
?
mi
from
Lincoln, NE
Click here to add this to my saved trials
Little Rock, Arkansas 72211
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Los Alamitos, California 90720
?
mi
from
Los Alamitos, CA
Click here to add this to my saved trials
Marietta, Georgia 30060
?
mi
from
Marietta, GA
Click here to add this to my saved trials
?
mi
from
Mason, OH
Click here to add this to my saved trials
Memphis, Tennessee 38119
?
mi
from
Memphis, TN
Click here to add this to my saved trials
Methuen, Massachusetts 01844
?
mi
from
Methuen, MA
Click here to add this to my saved trials
Mount Pleasant, South Carolina 29464
?
mi
from
Mount Pleasant, SC
Click here to add this to my saved trials
Naperville, Illinois 60563
?
mi
from
Naperville, IL
Click here to add this to my saved trials
30 Temple Street
Nashua, New Hampshire 03060
?
mi
from
Nashua, NH
Click here to add this to my saved trials
New York, New York 10022
?
mi
from
New York, NY
Click here to add this to my saved trials
2460 General Armistead Avenue
Norristown, Pennsylvania 20006
?
mi
from
Norristown, PA
Click here to add this to my saved trials
Norwich, Connecticut 06360
?
mi
from
Norwich, CT
Click here to add this to my saved trials
O'Fallon, Missouri 63368
?
mi
from
O'Fallon, MO
Click here to add this to my saved trials
Oakland Park, Florida 33334
?
mi
from
Oakland Park, FL
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Orlando, Florida 32819
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Phoenix, Arizona 85032
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Portland, Oregon 97210
?
mi
from
Portland, OR
Click here to add this to my saved trials
Riverside, California 92506
?
mi
from
Riverside, CA
Click here to add this to my saved trials
Rochester, New York 14618
?
mi
from
Rochester, NY
Click here to add this to my saved trials
609 West Dyke Road
Rogers, Arkansas 72758
?
mi
from
Rogers, AR
Click here to add this to my saved trials
4801 Weldon Spring Parkway
Saint Charles, Missouri 63301
?
mi
from
Saint Charles, MO
Click here to add this to my saved trials
Salt Lake City, Utah 84105
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Sherman Oaks, California 91403
?
mi
from
Sherman Oaks, CA
Click here to add this to my saved trials
Shreveport, Louisiana 71115
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
Smyrna, Georgia 30080
?
mi
from
Smyrna, GA
Click here to add this to my saved trials
851 Main Street
South Weymouth, Massachusetts 02190
?
mi
from
South Weymouth, MA
Click here to add this to my saved trials
Staten Island, New York 10312
?
mi
from
Staten Island, NY
Click here to add this to my saved trials
Temecula, California 92591
?
mi
from
Temecula, CA
Click here to add this to my saved trials
Toms River, New Jersey 08755
?
mi
from
Toms River, NJ
Click here to add this to my saved trials
Upland, California 91786
?
mi
from
Upland, CA
Click here to add this to my saved trials
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Wichita Falls, Texas 76309
?
mi
from
Wichita Falls, TX
Click here to add this to my saved trials
55 N Lake Ave
Worcester, Massachusetts 01655
(508) 856-8989
Univ of Massachusetts Med School As the commonwealth's only public medical school, we take seriously...
?
mi
from
Worcester, MA
Click here to add this to my saved trials