An Investigational Study of Immunotherapy Combinations With Chemotherapy in Patients With Gastric or Gastroesophageal Junction (GEJ) Cancers



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/3/2019
Start Date:October 4, 2018
End Date:July 1, 2023
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email

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A Randomized, Open-label, Phase II Clinical Trial of Relatlimab (Anti-LAG-3) and Nivolumab in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy as First-Line Treatment in Patients With Gastric or Gastroesophageal Junction Adenocarcinoma

The purpose of this study is to determine the efficacy and safety of investigational drug
relatlimab plus nivolumab in combination with chemotherapy in participants with unresectable,
untreated, locally advanced or metastatic gastric or GEJ cancer.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

- Histologically- or cytologically-confirmed diagnosis of unresectable, locally
advanced, or metastatic gastric cancer or GEJ adenocarcinoma

- No prior treatment with systemic treatment (including HER 2 inhibitors) given as
primary therapy for unresectable, locally advanced, or metastatic GC or GEJ
adenocarcinoma

- Tumor tissue must be provided for biomarker analyses

Exclusion Criteria:

- Participants with HER2 positive status

- Participants with known untreated central nervous system (CNS) metastases

- Uncontrolled or significant cardiovascular disease

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
21
sites
Sioux Falls, South Dakota 57104
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Aurora, Colorado 80045
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Baltimore, Maryland 21237
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Bismarck, North Dakota 58501
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Boston, Massachusetts 02111
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Boston, MA
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Capital Federal, Buenos Aires
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Capital Federal,
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Clovis, California 93611
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Dallas, Texas 75246
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Dallas, TX
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4500 S. Lancaster Rd.
Dallas, Texas 75216
800-849-3597
Dallas VA Medical Center VA North Texas Health Care System (VANTHCS) is a progressive health...
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Dallas, TX
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1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Phone: 626-218-3494
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duarte, CA
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Fargo, North Dakota 58122
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Fargo, ND
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92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Hackensack, NJ
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La Jolla, California 92093
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La Jolla, CA
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Los Angeles, California 90095
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Los Angeles, CA
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Los Angeles, CA
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333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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New Haven, CT
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New York, New York 10016
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New York, NY
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Newport Beach, California 92658
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Orange, California 92868
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Orange, CA
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Richmond, Virginia 23219
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Richmond, VA
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Seattle, Washington 98109
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Seattle, WA
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