Urinary Protein to Creatinine Ratio in Term Pregnant Women
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 16 - 55 |
| Updated: | 9/9/2018 |
| Start Date: | September 2018 |
| End Date: | November 2019 |
| Contact: | James N Anasti, MD |
| Email: | anastij@slhn.org |
| Phone: | 484-526-8878 |
Urinary Protein to Creatinine Ratio in Term Pregnant Women: What is the Effect of a Clean Catch Urine
This study will determine the incidence of elevated U Pr/Cr in normal term pregnant women. In
addition we will determine if a "clean catch" urine has an effect on the U Pr/Cr.
addition we will determine if a "clean catch" urine has an effect on the U Pr/Cr.
Clean catch urine should be used due to possible vaginal secretion contamination with falsely
elevated U Pr/Cr ratio. However, no supporting reference was found in the article and no
control group with random urine collection for comparison to clean catch specimen U Pr/Cr was
included in their study. The original studies that validated spot Pr/Cr urine as a predictor
of 24 -hour total urine protein used random non-clean catch random urines . They had an r
value of .93-.99 in estimating total protein excreted in 24 hours. At our institution we use
Siemens-base test to determine U Pr/Cr. In the product insert the company states that no
special patient preparation is necessary.
Thus, this study will determine the incidence of elevated U Pr/Cr in normal term pregnant
women. In addition we will determine if a "clean catch" urine has an effect on the U Pr/Cr.
elevated U Pr/Cr ratio. However, no supporting reference was found in the article and no
control group with random urine collection for comparison to clean catch specimen U Pr/Cr was
included in their study. The original studies that validated spot Pr/Cr urine as a predictor
of 24 -hour total urine protein used random non-clean catch random urines . They had an r
value of .93-.99 in estimating total protein excreted in 24 hours. At our institution we use
Siemens-base test to determine U Pr/Cr. In the product insert the company states that no
special patient preparation is necessary.
Thus, this study will determine the incidence of elevated U Pr/Cr in normal term pregnant
women. In addition we will determine if a "clean catch" urine has an effect on the U Pr/Cr.
Inclusion Criteria:
- women of 37 weeks gestation or greater
Exclusion Criteria:
- Urinary tract infections
- Hypertension
- Pre-eclampsia
- Renal dysfunction
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