Interventions Made to Preserve Cognitive Function



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:9/8/2018
Start Date:August 30, 2018
End Date:December 2023
Contact:Mara McAdams DeMarco, PhD
Email:mara@jhu.edu
Phone:410-502-1950

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Hemodialysis-based Interventions to Preserve Cognitive Function

This is a randomized, controlled trial to slow cognitive decline in adults undergoing
hemodialysis (HD). The investigators will test three interventions cognitive training (CT),
exercise training (ET), and combined cognitive and exercise training (CT+ET) relative to
standard of care (SC).

This will be a two by two factorial, randomized, controlled trial to slow cognitive decline
in adults undergoing hemodialysis (HD). The investigators primary objective is to determine
if receiving cognitive training (tablet-based brain games), exercise training (stationary
foot pedal), or combined cognitive and exercise training preserves executive function
relative to those with standard of care . The secondary objectives are to compare the rates
of end stage renal disease (ESRD)-specific clinical outcomes and patient centered outcomes
among those receiving CT, or ET, or CT+ET relative to those in SC. The investigators will
formally test whether receiving CT or ET will preserve executive function and receiving
combined CT+ET will preserve executive function better than CT or ET alone.

Inclusion Criteria:

- 18 years or older at enrollment

- English speaking

- within 3 months to 3 years of initiating hemodialysis

- receiving hemodialysis at participating dialysis centers

Exclusion Criteria: Patients with the following conditions will be excluded:

- Pregnancy

- Angina Pectoris

- Chronic lung disease requiring oxygen

- Musculoskeletal conditions that limit mobility

- Upper or lower extremity amputation

- Orthopedic disorders exacerbated by physical activity

- Femoral arteriovenous (AV) access

- Hepatitis B infection

- Blindness/Legal blindness

In addition to conditions outlined above, patients who are currently incarcerated will be
excluded from the study.
We found this trial at
1
site
Baltimore, Maryland 21287
Phone: 443-287-0613
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mi
from
Baltimore, MD
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