Hyperglycemia, Exercise, and Endothelial Function



Status:Recruiting
Conditions:Hematology, Diabetes
Therapuetic Areas:Endocrinology, Hematology
Healthy:No
Age Range:18 - 35
Updated:1/11/2019
Start Date:October 15, 2018
End Date:September 1, 2019
Contact:Darren P Casey, PhD
Email:darren-casey@uiowa.edu
Phone:319-384-1009

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Trial Summary
Trial Overview
Inclusion Criteria

Effect of Short-Term Glucose Loading on Vascular Function

The main purpose of this study is to determine if exercise preserves vascular function during
hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days.
Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU)
structured exercise group.

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are
associated with impaired endothelial function. Both a single bout of exercise and chronic
exercise training are associated with improvements in vascular endothelial function. It
remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Inclusion Criteria:

- Healthy young men 18-35 years of age.

Exclusion Criteria:

- Hypertension,

- Hyperlipidemia,

- Smoking,

- Heart disease,

- Chest pain upon exertion,

- Previous heart surgeries or history of arrhythmias,

- Diabetes,

- Obesity (body mass index ≥30kg/m2),

- Kidney disease,

- Pulmonary disease,

- Autonomic disorders,

- Individuals whom engage in structured exercise (≥30min, ≥2d/wk),

- Current use of medications which influence outcome measures
We found this trial at
1
site
Medical Education Building
375 Newton Road
Iowa City, Iowa 52242
Phone: 319-334-1009
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from
Iowa City, IA
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