Utilization of Somatic Tissue Oxygen Saturation Monitoring in Pregnant Women
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/31/2018 |
| Start Date: | October 1, 2018 |
| End Date: | October 1, 2019 |
| Contact: | Aymen Alilan |
| Email: | aymen.alian@yale.edu |
| Phone: | 203-785-2802 |
Perioperative Clinical Utilization of Somatic Tissue Oxygen Saturation Monitoring in Pregnant Women
The purpose of this study is to compare 3 methods of assessing endothelial function in
healthy female volunteers and pregnant women with and without pregnancy induced hypertension.
The methods under comparison are simultaneous tissue oxygen saturation (StO2), EndoPAT and
Sphygmocor (pregnant women only). 35 participants (15 healthy, 10 pregnant normal blood
pressure, 10 pregnant with hypertension) will be enrolled.
healthy female volunteers and pregnant women with and without pregnancy induced hypertension.
The methods under comparison are simultaneous tissue oxygen saturation (StO2), EndoPAT and
Sphygmocor (pregnant women only). 35 participants (15 healthy, 10 pregnant normal blood
pressure, 10 pregnant with hypertension) will be enrolled.
In both normotensive women and others with pregnancy induced hypertension, in previous
research simultaneous tissue oxygen saturation (StO2) were measured in both forearms, with a
blood pressure cuff above the tissue oximetry probe on one side.
StO2 values were continuously monitored on each side during unilateral blood pressure (BP)
cuff inflation (to suprasystolic pressure for 3 min), and then during deflation. Despite
similarity in the forearm StO2 decline observed with cuff inflation in all women, the rise
following cuff deflation - indicative of reactive hyperemia - appeared reduced in
hypertensive patients, suggesting a relationship with impaired endothelial reserve.
research simultaneous tissue oxygen saturation (StO2) were measured in both forearms, with a
blood pressure cuff above the tissue oximetry probe on one side.
StO2 values were continuously monitored on each side during unilateral blood pressure (BP)
cuff inflation (to suprasystolic pressure for 3 min), and then during deflation. Despite
similarity in the forearm StO2 decline observed with cuff inflation in all women, the rise
following cuff deflation - indicative of reactive hyperemia - appeared reduced in
hypertensive patients, suggesting a relationship with impaired endothelial reserve.
Inclusion Criteria:
Non-pregnant group:
1. > 18 years of age
2. Male or female
Pregnant group:
1. > 18 years of age
2. Pregnant women > 20 weeks
3. Diagnosis of Pre-eclampsia characterized as Systolic BP > 140 mmHg, diastolic BP > 90
mmHg after 20 weeks of gestation accompanied by new onset of proteinuria.
4. Normotensive, not meeting criteria in #3
Exclusion Criteria:
Non-pregnant group:
1. Raynaud's Disease
2. Adhesive tape allergy
3. Recent Myocardial Infarction (< 3 months)
4. Congestive Heart Failure
Pregnant group:
1. Raynaud's Disease
2. Adhesive tape allergy
3. Recent Myocardial Infarction (< 3 months)
4. Congestive Heart Failure
5. Hemodynamically unstable (SBP < 90 mmHg)
6. Fetal distress
We found this trial at
1
site
20 York St, N20 York St,
New Haven, Connecticut 06520
New Haven, Connecticut 06520
(203) 688-4242
Phone: 203-785-2802
Yale-New Haven Hospital Relying on the skill and expertise of more than 4,500 university and...
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